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LSM14A LSM14A, mRNA processing body assembly factor [ Homo sapiens (human) ]

Gene ID: 26065, updated on 5-Aug-2018
Official Symbol
LSM14Aprovided by HGNC
Official Full Name
LSM14A, mRNA processing body assembly factorprovided by HGNC
Primary source
HGNC:HGNC:24489
See related
Ensembl:ENSG00000257103 MIM:610677; Vega:OTTHUMG00000180491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAP55; FAM61A; RAP55A; C19orf13
Summary
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 23.9), lymph node (RPKM 21.2) and 25 other tissues See more
Orthologs
See LSM14A in Genome Data Viewer
Location:
19q13.11
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (34172447..34229515)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (34663352..34720420)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4X pseudogene 21 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 3 Neighboring gene KIAA0355 Neighboring gene ribosomal protein L29 pseudogene 33 Neighboring gene glucose-6-phosphate isomerase

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp434D1335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RIG-I signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic mRNA processing body assembly IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic mRNA processing body assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
Preferred Names
protein LSM14 homolog A
Names
LSM14 homolog A
LSM14A, SCD6 homolog A
RNA-associated protein 55
RNA-associated protein 55A
alphaSNBP
family with sequence similarity 61, member A
hRAP55
hRAP55A
protein SCD6 homolog
putative alpha-synuclein-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114093.1NP_001107565.1  protein LSM14 homolog A isoform a

    See identical proteins and their annotated locations for NP_001107565.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform a. While isoforms a and b are of the same length, their C-termini are different.
    Source sequence(s)
    AB069974, AC010614, BC016842
    Consensus CDS
    CCDS46040.1
    UniProtKB/Swiss-Prot
    Q8ND56
    Related
    ENSP00000413964.3, OTTHUMP00000264468, ENST00000433627.9, OTTHUMT00000451576
    Conserved Domains (2) summary
    cd01736
    Location:477
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:291399
    FDF; FDF domain
  2. NM_015578.2NP_056393.2  protein LSM14 homolog A isoform b

    See identical proteins and their annotated locations for NP_056393.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1 and encodes isoform b. While isoforms a and b are of the same length, their C-termini are different.
    Source sequence(s)
    AC010614, BC016842
    Consensus CDS
    CCDS12435.1
    UniProtKB/Swiss-Prot
    Q8ND56
    Related
    ENSP00000446271.2, OTTHUMP00000264465, ENST00000544216.7, OTTHUMT00000451573
    Conserved Domains (2) summary
    cd01736
    Location:477
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:291399
    FDF; FDF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    34172447..34229515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026577.2XP_016882066.1  protein LSM14 homolog A isoform X6

  2. XM_017026576.2XP_016882065.1  protein LSM14 homolog A isoform X5

  3. XM_017026575.2XP_016882064.1  protein LSM14 homolog A isoform X4

  4. XM_005258719.5XP_005258776.1  protein LSM14 homolog A isoform X1

    See identical proteins and their annotated locations for XP_005258776.1

    Conserved Domains (2) summary
    cd01736
    Location:477
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:291399
    FDF; FDF domain
  5. XM_005258721.5XP_005258778.1  protein LSM14 homolog A isoform X3

    See identical proteins and their annotated locations for XP_005258778.1

    Conserved Domains (2) summary
    cd01736
    Location:477
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:256338
    FDF; FDF domain
  6. XM_005258720.5XP_005258777.1  protein LSM14 homolog A isoform X2

    See identical proteins and their annotated locations for XP_005258777.1

    Conserved Domains (2) summary
    pfam09532
    Location:232340
    FDF; FDF domain
    pfam12701
    Location:680
    LSM14; Scd6-like Sm domain
  7. XM_011526708.3XP_011525010.1  protein LSM14 homolog A isoform X7

    See identical proteins and their annotated locations for XP_011525010.1

    Conserved Domains (2) summary
    pfam09532
    Location:197279
    FDF; FDF domain
    pfam12701
    Location:680
    LSM14; Scd6-like Sm domain

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003315963.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    20188..77263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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