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LTN1 listerin E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 26046, updated on 5-Apr-2020

Summary

Official Symbol
LTN1provided by HGNC
Official Full Name
listerin E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:13082
See related
Ensembl:ENSG00000198862 MIM:613083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF160; ZNF294; C21orf10; C21orf98
Summary
Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in thyroid (RPKM 7.5), placenta (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See LTN1 in Genome Data Viewer
Location:
21q21.3
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (28928144..28992988, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (30300466..30365277, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 7 Neighboring gene THUMP domain containing 1 pseudogene 1 Neighboring gene uncharacterized LOC105372766 Neighboring gene ribosomal protein L23 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11053, KIAA0714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
 
rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome-associated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase listerin
Names
RING-type E3 ubiquitin transferase listerin
ring finger protein 160
zinc finger protein 294
NP_001307695.2
NP_056380.3
XP_006724050.1
XP_016883805.1
XP_016883806.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320766.2NP_001307695.2  E3 ubiquitin-protein ligase listerin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame exon in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AB018257, AF260011, BC029371, BC140790, BF059116, HY001556
    Conserved Domains (1) summary
    COG5219
    Location:14631751
    COG5219; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
  2. NM_015565.3NP_056380.3  E3 ubiquitin-protein ligase listerin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB018257, BC140790, BF059116, DB452437
    Consensus CDS
    CCDS33527.2
    Related
    ENSP00000354977.4, ENST00000361371.10
    Conserved Domains (1) summary
    COG5219
    Location:14771765
    COG5219; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    28928144..28992988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028316.2XP_016883805.1  E3 ubiquitin-protein ligase listerin isoform X1

  2. XM_017028317.1XP_016883806.1  E3 ubiquitin-protein ligase listerin isoform X2

  3. XM_006723987.4XP_006724050.1  E3 ubiquitin-protein ligase listerin isoform X3

    Conserved Domains (1) summary
    COG5219
    Location:105308
    COG5219; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
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