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LRP10 LDL receptor related protein 10 [ Homo sapiens (human) ]

Gene ID: 26020, updated on 25-Nov-2021

Summary

Official Symbol
LRP10provided by HGNC
Official Full Name
LDL receptor related protein 10provided by HGNC
Primary source
HGNC:HGNC:14553
See related
Ensembl:ENSG00000197324 MIM:609921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRP9; LRP-10; MST087; MSTP087
Summary
This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in esophagus (RPKM 34.1), colon (RPKM 29.6) and 25 other tissues See more
Orthologs
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Genomic context

See LRP10 in Genome Data Viewer
Location:
14q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (22871613..22881713)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23340949..23350922)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 14 Neighboring gene Sharpr-MPRA regulatory region 964 Neighboring gene RRAD and GEM like GTPase 2 Neighboring gene RNA binding motif protein 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8675, MGC142274, MGC142276, DKFZp564C1940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables low-density lipoprotein particle receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in inner ear development IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
low-density lipoprotein receptor-related protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051090.1 RefSeqGene

    Range
    5128..15101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329226.2NP_001316155.1  low-density lipoprotein receptor-related protein 10 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL135998, AW009640
    Consensus CDS
    CCDS86372.1
    UniProtKB/Swiss-Prot
    Q7Z4F1
    Related
    ENSP00000447559.1, ENST00000546834.5
  2. NM_014045.5NP_054764.2  low-density lipoprotein receptor-related protein 10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_054764.2

    Status: REVIEWED

    Source sequence(s)
    AI692207, AL135998, AW009640, AY358399, BM846255, BM981286, BM997452, BQ774170
    Consensus CDS
    CCDS9578.1
    UniProtKB/Swiss-Prot
    Q7Z4F1
    Related
    ENSP00000352601.4, ENST00000359591.9
    Conserved Domains (3) summary
    PRK04654
    Location:573675
    PRK04654; sec-independent translocase; Provisional
    cd00041
    Location:192302
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:399433
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    22871613..22881713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267510.1XP_005267567.1  low-density lipoprotein receptor-related protein 10 isoform X1

    See identical proteins and their annotated locations for XP_005267567.1

    Conserved Domains (3) summary
    PRK04654
    Location:581683
    PRK04654; sec-independent translocase; Provisional
    cd00041
    Location:200310
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:407441
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
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