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TKFC triokinase and FMN cyclase [ Homo sapiens (human) ]

Gene ID: 26007, updated on 20-Apr-2020

Summary

Official Symbol
TKFCprovided by HGNC
Official Full Name
triokinase and FMN cyclaseprovided by HGNC
Primary source
HGNC:HGNC:24552
See related
Ensembl:ENSG00000149476 MIM:615844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAK; NET45; TKFCD
Summary
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]
Expression
Broad expression in duodenum (RPKM 30.4), small intestine (RPKM 22.4) and 23 other tissues See more
Orthologs

Genomic context

See TKFC in Genome Data Viewer
Location:
11q12.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (61333182..61353426)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61100654..61120898)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene von Willebrand factor C and EGF domains Neighboring gene damage specific DNA binding protein 1 Neighboring gene cytochrome b561 family member A3 Neighboring gene transmembrane protein 138 Neighboring gene transmembrane protein 216

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5621, DKFZp586B1621

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
FAD-AMP lyase (cyclizing) activity IDA
Inferred from Direct Assay
more info
PubMed 
glycerone kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerone kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
triokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
triokinase/FMN cyclase
Names
ATP-dependent dihydroxyacetone kinase
DHA kinase
Dha kinase/FMN cyclase
FAD-AMP lyase cyclic FMN forming
FAD-AMP lyase cyclizing
bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
dihydroxyacetone kinase 2 homolog
glycerone kinase
testis tissue sperm-binding protein Li 84P
NP_001338905.1
NP_001338906.1
NP_001338907.1
NP_001338908.1
NP_001338909.1
NP_056348.2
XP_011543214.1
XP_016873006.1
XP_016873007.1
XP_016873008.1
XP_016873009.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351976.2NP_001338905.1  triokinase/FMN cyclase isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AP003108
    Consensus CDS
    CCDS8003.1
    Conserved Domains (1) summary
    TIGR02361
    Location:4558
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
  2. NM_001351977.2NP_001338906.1  triokinase/FMN cyclase isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AP003108
    Conserved Domains (1) summary
    cl10557
    Location:4526
    Dak1; Dak1 domain
  3. NM_001351978.1NP_001338907.1  triokinase/FMN cyclase isoform c

    Status: REVIEWED

    Source sequence(s)
    AP003108
    Conserved Domains (1) summary
    cl10557
    Location:4525
    Dak1; Dak1 domain
  4. NM_001351979.2NP_001338908.1  triokinase/FMN cyclase isoform d

    Status: REVIEWED

    Source sequence(s)
    AP003108
    Related
    ENSP00000432539.1, ENST00000529479.5
    Conserved Domains (1) summary
    cl10557
    Location:4526
    Dak1; Dak1 domain
  5. NM_001351980.2NP_001338909.1  triokinase/FMN cyclase isoform e

    Status: REVIEWED

    Source sequence(s)
    AP003108
    Conserved Domains (1) summary
    cl10557
    Location:1456
    Dak1; Dak1 domain
  6. NM_015533.4NP_056348.2  triokinase/FMN cyclase isoform b

    See identical proteins and their annotated locations for NP_056348.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AP003108, BC001341, BF197629, DA932478, DB056724
    Consensus CDS
    CCDS8003.1
    UniProtKB/Swiss-Prot
    Q3LXA3
    UniProtKB/TrEMBL
    A0A140VJH7
    Related
    ENSP00000378360.3, ENST00000394900.7
    Conserved Domains (1) summary
    TIGR02361
    Location:4558
    dak_ATP; dihydroxyacetone kinase, ATP-dependent

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    61333182..61353426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017518.1XP_016873007.1  triokinase/FMN cyclase isoform X3

    Conserved Domains (3) summary
    TIGR02361
    Location:50571
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:65381
    Dak1; Dak1 domain
    pfam02734
    Location:444571
    Dak2; DAK2 domain
  2. XM_011544912.3XP_011543214.1  triokinase/FMN cyclase isoform X1

    See identical proteins and their annotated locations for XP_011543214.1

    Conserved Domains (3) summary
    TIGR02361
    Location:50572
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:65381
    Dak1; Dak1 domain
    pfam02734
    Location:444572
    Dak2; DAK2 domain
  3. XM_017017517.1XP_016873006.1  triokinase/FMN cyclase isoform X2

    Conserved Domains (3) summary
    TIGR02361
    Location:50604
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:65381
    Dak1; Dak1 domain
    pfam02734
    Location:444604
    Dak2; DAK2 domain
  4. XM_017017520.1XP_016873009.1  triokinase/FMN cyclase isoform X5

    Conserved Domains (3) summary
    TIGR02361
    Location:50572
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:65381
    Dak1; Dak1 domain
    pfam02734
    Location:444572
    Dak2; DAK2 domain
  5. XM_017017519.2XP_016873008.1  triokinase/FMN cyclase isoform X4

    Conserved Domains (3) summary
    TIGR02361
    Location:4526
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:19335
    Dak1; Dak1 domain
    pfam02734
    Location:398526
    Dak2; DAK2 domain
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