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Tkfc triokinase, FMN cyclase [ Mus musculus (house mouse) ]

Gene ID: 225913, updated on 15-Apr-2019

Summary

Official Symbol
Tkfcprovided by MGI
Official Full Name
triokinase, FMN cyclaseprovided by MGI
Primary source
MGI:MGI:2385084
See related
Ensembl:ENSMUSG00000034371
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dak; BC021917
Expression
Biased expression in liver adult (RPKM 116.1), kidney adult (RPKM 103.3) and 14 other tissues See more
Orthologs

Genomic context

See Tkfc in Genome Data Viewer
Location:
19; 19 A
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (10592197..10605482, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (10666687..10678748, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216 Neighboring gene transmembrane protein 138 Neighboring gene cytochrome b561 family, member A3 Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from BioSystems

General gene information

Homology

Clone Names

  • MGC28742

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
FAD-AMP lyase (cyclizing) activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
glycerone kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerone kinase activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
triokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
triokinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
 
cellular carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IC
Inferred by Curator
more info
PubMed 
glycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycolytic process through fructose-1-phosphate IC
Inferred by Curator
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
triokinase/FMN cyclase
Names
bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
dihydroxyacetone kinase 2 homolog
NP_663471.1
XP_006527004.1
XP_006527005.1
XP_006527006.1
XP_006527007.1
XP_011245525.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145496.1NP_663471.1  triokinase/FMN cyclase

    See identical proteins and their annotated locations for NP_663471.1

    Status: PROVISIONAL

    Source sequence(s)
    BC021917
    Consensus CDS
    CCDS37914.1
    UniProtKB/Swiss-Prot
    Q8VC30
    Related
    ENSMUSP00000044556.6, ENSMUST00000037678.6
    Conserved Domains (3) summary
    TIGR02361
    Location:4570
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:19335
    Dak1; Dak1 domain
    pfam02734
    Location:398571
    Dak2; DAK2 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    10592197..10605482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526942.2XP_006527005.1  triokinase/FMN cyclase isoform X2

    See identical proteins and their annotated locations for XP_006527005.1

    UniProtKB/Swiss-Prot
    Q8VC30
    Related
    ENSMUSP00000157520.1, ENSMUST00000236607.1
    Conserved Domains (3) summary
    TIGR02361
    Location:4570
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:19335
    Dak1; Dak1 domain
    pfam02734
    Location:398571
    Dak2; DAK2 domain
  2. XM_006526944.3XP_006527007.1  triokinase/FMN cyclase isoform X2

    See identical proteins and their annotated locations for XP_006527007.1

    UniProtKB/Swiss-Prot
    Q8VC30
    Related
    ENSMUSP00000158068.1, ENSMUST00000236950.1
    Conserved Domains (3) summary
    TIGR02361
    Location:4570
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:19335
    Dak1; Dak1 domain
    pfam02734
    Location:398571
    Dak2; DAK2 domain
  3. XM_006526941.3XP_006527004.1  triokinase/FMN cyclase isoform X1

    Conserved Domains (3) summary
    TIGR02361
    Location:56622
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:71387
    Dak1; Dak1 domain
    pfam02734
    Location:450623
    Dak2; DAK2 domain
  4. XM_006526943.3XP_006527006.1  triokinase/FMN cyclase isoform X2

    See identical proteins and their annotated locations for XP_006527006.1

    UniProtKB/Swiss-Prot
    Q8VC30
    Conserved Domains (3) summary
    TIGR02361
    Location:4570
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:19335
    Dak1; Dak1 domain
    pfam02734
    Location:398571
    Dak2; DAK2 domain
  5. XM_011247223.2XP_011245525.1  triokinase/FMN cyclase isoform X3

    Conserved Domains (3) summary
    TIGR02361
    Location:2565
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
    pfam02733
    Location:14330
    Dak1; Dak1 domain
    pfam02734
    Location:393566
    Dak2; DAK2 domain
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