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ULK3 unc-51 like kinase 3 [ Homo sapiens (human) ]

Gene ID: 25989, updated on 17-Jun-2019

Summary

Official Symbol
ULK3provided by HGNC
Official Full Name
unc-51 like kinase 3provided by HGNC
Primary source
HGNC:HGNC:19703
See related
Ensembl:ENSG00000140474 MIM:613472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in skin (RPKM 31.2), small intestine (RPKM 22.9) and 25 other tissues See more
Orthologs

Genomic context

See ULK3 in Genome Data Viewer
Location:
15q24.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74836116..74843211, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75128459..75135552, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene lectin, mannose binding 1 like Neighboring gene uncharacterized LOC105370897 Neighboring gene complexin 3 Neighboring gene microRNA 6882 Neighboring gene secretory carrier membrane protein 2 Neighboring gene mannose phosphate isomerase Neighboring gene family with sequence similarity 219 member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
NHGRI GWA Catalog
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
NHGRI GWA Catalog
Genome-wide association study of blood pressure and hypertension.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
NHGRI GWA Catalog

Pathways from BioSystems

  • Hedgehog 'on' state, organism-specific biosystem (from REACTOME)
    Hedgehog 'on' state, organism-specific biosystemHedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
    Signaling by Hedgehog, organism-specific biosystemHedgehog (Hh) is a secreted morphogen that regulates developmental processes in vertebrates including limb bud formation, neural tube patterning, cell growth and differentiation (reviewed in Hui and ...
  • Target Of Rapamycin (TOR) Signaling, organism-specific biosystem (from WikiPathways)
    Target Of Rapamycin (TOR) Signaling, organism-specific biosystemTOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central r...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90566, DKFZp434C131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy TAS
Traceable Author Statement
more info
PubMed 
cellular senescence TAS
Traceable Author Statement
more info
PubMed 
negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
ciliary tip TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagophore assembly site TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase ULK3
NP_001092906.3
NP_001271293.2
NP_001271294.1
XP_005254346.1
XP_016877557.1
XP_016877558.1
XP_016877559.1
XP_016877560.1
XP_016877561.1
XP_024305665.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099436.4NP_001092906.3  serine/threonine-protein kinase ULK3 isoform a

    See identical proteins and their annotated locations for NP_001092906.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK293181, AK299380, AL117482, BC157884
    Consensus CDS
    CCDS45305.1
    UniProtKB/Swiss-Prot
    Q6PHR2
    UniProtKB/TrEMBL
    B4DDG2
    Related
    ENSP00000400312.2, ENST00000440863.7
    Conserved Domains (4) summary
    smart00220
    Location:14270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02684
    Location:279353
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cd14121
    Location:18269
    STKc_ULK3; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3
    cl00299
    Location:374449
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  2. NM_001284364.3NP_001271293.2  serine/threonine-protein kinase ULK3 isoform b

    See identical proteins and their annotated locations for NP_001271293.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AI677802, AK293181, BC157884
    Consensus CDS
    CCDS76779.1
    UniProtKB/Swiss-Prot
    Q6PHR2
    UniProtKB/TrEMBL
    B4DDG2
    Related
    ENSP00000456051.1, ENST00000569437.5
    Conserved Domains (4) summary
    smart00220
    Location:14270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02684
    Location:279353
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cd14121
    Location:18269
    STKc_ULK3; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3
    cl00299
    Location:374442
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  3. NM_001284365.3NP_001271294.1  serine/threonine-protein kinase ULK3 isoform c

    See identical proteins and their annotated locations for NP_001271294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK293181, AL117482, BI829133
    UniProtKB/Swiss-Prot
    Q6PHR2
    UniProtKB/TrEMBL
    B4DDG2
    Conserved Domains (4) summary
    smart00220
    Location:1153
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02684
    Location:162236
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cl00299
    Location:257332
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:1152
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_104307.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI677802, AL117482
    Related
    ENST00000570276.5
  2. NR_104308.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate internal segment and uses alternate splice sites at two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI677802, BC048289, BC056423, BI829133
    Related
    ENST00000561725.5
  3. NR_104309.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate internal segment and use an alternate splice sites at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI677802, BC056423, BI829133
    Related
    ENST00000566479.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74836116..74843211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022070.1XP_016877559.1  serine/threonine-protein kinase ULK3 isoform X3

  2. XM_017022068.1XP_016877557.1  serine/threonine-protein kinase ULK3 isoform X2

  3. XM_017022071.1XP_016877560.1  serine/threonine-protein kinase ULK3 isoform X4

    UniProtKB/TrEMBL
    B4DFS6
    Conserved Domains (3) summary
    cd02684
    Location:189263
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cl00299
    Location:284352
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:1179
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017022069.1XP_016877558.1  serine/threonine-protein kinase ULK3 isoform X3

  5. XM_005254289.2XP_005254346.1  serine/threonine-protein kinase ULK3 isoform X1

    See identical proteins and their annotated locations for XP_005254346.1

    UniProtKB/Swiss-Prot
    Q6PHR2
    Related
    ENSP00000457853.1, ENST00000568667.5
    Conserved Domains (4) summary
    smart00220
    Location:46281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02684
    Location:290364
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cd14121
    Location:46280
    STKc_ULK3; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3
    cl00299
    Location:385460
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  6. XM_017022072.1XP_016877561.1  serine/threonine-protein kinase ULK3 isoform X4

    UniProtKB/TrEMBL
    B4DFS6
    Conserved Domains (3) summary
    cd02684
    Location:189263
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cl00299
    Location:284352
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:1179
    PKc_like; Protein Kinases, catalytic domain
  7. XM_024449897.1XP_024305665.1  serine/threonine-protein kinase ULK3 isoform X4

    Conserved Domains (3) summary
    cd02684
    Location:189263
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cl00299
    Location:284352
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:1179
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_931792.2 RNA Sequence

  2. XR_001751210.2 RNA Sequence

  3. XR_001751209.2 RNA Sequence

  4. XR_931791.2 RNA Sequence

  5. XR_931790.2 RNA Sequence

  6. XR_931789.2 RNA Sequence

    Related
    ENST00000647587.1
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