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VIRMA vir like m6A methyltransferase associated [ Homo sapiens (human) ]

Gene ID: 25962, updated on 5-Nov-2024

Summary

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Official Symbol
VIRMAprovided by HGNC
Official Full Name
vir like m6A methyltransferase associatedprovided by HGNC
Primary source
HGNC:HGNC:24500
See related
Ensembl:ENSG00000164944 MIM:616447; AllianceGenome:HGNC:24500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSTP054; fSAP121; KIAA1429
Summary
Enables RNA binding activity. Involved in mRNA processing. Located in RNA N6-methyladenosine methyltransferase complex; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 11.6), ovary (RPKM 8.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See VIRMA in Genome Data Viewer
Location:
8q22.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94487689..94553469, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (95612521..95678291, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95499917..95565697, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4X pseudogene 10 Neighboring gene RAD54 homolog B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:95447028-95447528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19366 Neighboring gene NANOG hESC enhancer GRCh37_chr8:95456748-95457280 Neighboring gene fibrinogen silencer binding protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:95480258-95480884 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:95480885-95481510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27631 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:95546863-95547362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27632 Neighboring gene ribosomal protein L31 pseudogene Neighboring gene VIRMA divergent transcript Neighboring gene long intergenic non-protein coding RNA 2894

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The component of the m(6)A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors. Miranda-Gonçalves V, et al. J Exp Clin Cancer Res, 2021 Aug 25. PMID 34446080, Free PMC Article
  2. KIAA1429 mediates epithelial mesenchymal transition in sorafenib-resistant hepatocellular carcinoma through m6A methylation modification. Kuang Y, et al. Cancer Med, 2023 Mar. PMID 36420693, Free PMC Article
  3. Role and mechanism of KIAA1429 in regulating cellular ferroptosis and radioresistance in colorectal cancer. Chen H, et al. Biomol Biomed, 2024 Oct 17. PMID 38843497,
  4. m6A 'writer' KIAA1429 regulates the proliferation and migration of endothelial cells in atherosclerosis. Rong J, et al. Mol Biotechnol, 2023 Jul. PMID 36463391, Free PMC Article
  5. KIAA1429 promotes tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/ MAPK pathway in an m(6)A-dependent manner. Lin X, et al. Drug Resist Updat, 2023 Jan. PMID 36493511

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N6-Methyladenosine Methyltransferase Component KIAA1429 Is a Potential Target of Cancer Therapy.
    Title: N6-Methyladenosine Methyltransferase Component KIAA1429 Is a Potential Target of Cancer Therapy.
  2. KIAA1429 regulates lung adenocarcinoma proliferation and metastasis through the PI3K/AKT pathway by modulating ARHGAP30 expression.
    Title: KIAA1429 regulates lung adenocarcinoma proliferation and metastasis through the PI3K/AKT pathway by modulating ARHGAP30 expression.
  3. KIAA1429 Induces m6A Modification of LINC01106 to Enhance the Malignancy of Lung Adenocarcinoma Cells via the JAK/STAT3 Pathway.
    Title: KIAA1429 Induces m6A Modification of LINC01106 to Enhance the Malignancy of Lung Adenocarcinoma Cells via the JAK/STAT3 Pathway.
  4. VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.
    Title: VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.
  5. Role and mechanism of KIAA1429 in regulating cellular ferroptosis and radioresistance in colorectal cancer.
    Title: Role and mechanism of KIAA1429 in regulating cellular ferroptosis and radioresistance in colorectal cancer.
  6. Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3beta.
    Title: Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3β.
  7. KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.
    Title: KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.
  8. Inhibin A contributes to the tumorigenesis of oral squamous cell carcinoma by KIAA1429-mediated m6A modification.
    Title: Inhibin A contributes to the tumorigenesis of oral squamous cell carcinoma by KIAA1429-mediated m6A modification.
  9. KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.
    Title: KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.
  10. KIAA1429 protects hepatocellular carcinoma cells from ferroptotic cell death with a m[6] A-dependent posttranscriptional modification of SLC7A11.
    Title: KIAA1429 protects hepatocellular carcinoma cells from ferroptotic cell death with a m(6) A-dependent posttranscriptional modification of SLC7A11.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138493, MGC141940, DKFZp434I116, DKFZp781B2117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA N6-methyladenosine methyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
protein virilizer homolog
Names
functional spliceosome-associated protein 121
virilizer homolog

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015496.5 → NP_056311.2  protein virilizer homolog isoform 1

    See identical proteins and their annotated locations for NP_056311.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA731668, AB037850, AC023632, AL832487, BC113380
    Consensus CDS
    CCDS34923.1
    UniProtKB/Swiss-Prot
    Q2M1N0, Q69YN4, Q6AHX9, Q6NT78, Q7Z6C7, Q8IXH4, Q9BTH4, Q9H9C9, Q9NWR3, Q9P2B8, Q9UFW1
    Related
    ENSP00000297591.5, ENST00000297591.10
    Conserved Domains (2) summary
    pfam15502
    Location:1703 → 1808
    MPLKIP; M-phase-specific PLK1-interacting protein
    pfam15912
    Location:5 → 235
    VIR_N; Virilizer, N-terminal

  2. NM_183009.3 → NP_892121.1  protein virilizer homolog isoform 2

    See identical proteins and their annotated locations for NP_892121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF116724, BC113380
    Consensus CDS
    CCDS47894.1
    UniProtKB/Swiss-Prot
    Q69YN4
    Related
    ENSP00000398390.2, ENST00000421249.2
    Conserved Domains (1) summary
    pfam15912
    Location:5 → 235
    VIR_N; Virilizer, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    94487689..94553469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421677.1 → XP_047277633.1  protein virilizer homolog isoform X1

  2. XM_047421678.1 → XP_047277634.1  protein virilizer homolog isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    95612521..95678291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360260.1 → XP_054216235.1  protein virilizer homolog isoform X1

  2. XM_054360261.1 → XP_054216236.1  protein virilizer homolog isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69YN4.2 GenPept UniProtKB/Swiss-Prot:Q69YN4

Gene LinkOut

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