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Virma vir like m6A methyltransferase associated [ Mus musculus (house mouse) ]

Gene ID: 66185, updated on 11-Apr-2024

Summary

Official Symbol
Virmaprovided by MGI
Official Full Name
vir like m6A methyltransferase associatedprovided by MGI
Primary source
MGI:MGI:1913435
See related
Ensembl:ENSMUSG00000040720 AllianceGenome:MGI:1913435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa1429; mKIAA1429; 1110037F02Rik; 4930422M05Rik
Summary
Predicted to be involved in mRNA alternative polyadenylation and mRNA methylation. Predicted to act upstream of or within RNA splicing and mRNA processing. Located in cytoplasm and nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Orthologous to human VIRMA (vir like m6A methyltransferase associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 9.4), CNS E11.5 (RPKM 9.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 A1; 4 5.11 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11485958..11551143)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11485958..11551143)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09598 Neighboring gene predicted gene, 35631 Neighboring gene predicted gene 11821 Neighboring gene STARR-positive B cell enhancer ABC_E4613 Neighboring gene STARR-seq mESC enhancer starr_09599 Neighboring gene STARR-positive B cell enhancer ABC_E338 Neighboring gene STARR-seq mESC enhancer starr_09600 Neighboring gene STARR-positive B cell enhancer ABC_E4614 Neighboring gene predicted gene, 53245 Neighboring gene predicted gene, 35693 Neighboring gene RAD54 homolog B (S. cerevisiae) Neighboring gene fibrinogen silencer binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA alternative polyadenylation ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081183.1NP_001074652.1  protein virilizer homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732538, AL772170
    Consensus CDS
    CCDS38693.1
    UniProtKB/TrEMBL
    E9PZY8
    Related
    ENSMUSP00000103943.3, ENSMUST00000108307.3
    Conserved Domains (2) summary
    pfam15502
    Location:17521857
    MPLKIP; M-phase-specific PLK1-interacting protein
    pfam15912
    Location:5236
    VIR_N; Virilizer, N-terminal
  2. NM_001347055.1NP_001333984.1  protein virilizer homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL732538, AL772170
    Consensus CDS
    CCDS84705.1
    UniProtKB/Swiss-Prot
    A2AIV1, A2AIV2, Q3TDQ3, Q3TRR9, Q3U1Z2, Q80TD6, Q8C758, Q8K151, Q9CSI3
    Related
    ENSMUSP00000058078.7, ENSMUST00000059914.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11485958..11551143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)