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CLIC4 chloride intracellular channel 4 [ Homo sapiens (human) ]

Gene ID: 25932, updated on 20-Jan-2019

Summary

Official Symbol
CLIC4provided by HGNC
Official Full Name
chloride intracellular channel 4provided by HGNC
Primary source
HGNC:HGNC:13518
See related
Ensembl:ENSG00000169504 MIM:606536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1; huH1; p64H1; CLIC4L; MTCLIC
Summary
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 129.1), kidney (RPKM 121.8) and 25 other tissues See more
Orthologs

Genomic context

See CLIC4 in Genome Data Viewer
Location:
1p36.11
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (24745269..24844324)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (25071760..25170815)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 8 Neighboring gene non-compact myelin associated protein Neighboring gene serine and arginine repetitive matrix 1 Neighboring gene RNA, U6 small nuclear 1208, pseudogene Neighboring gene uncharacterized LOC105376876 Neighboring gene runt related transcription factor 3 Neighboring gene microRNA 6731

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38640, DKFZp566G223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cellular response to calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
chloride transport NAS
Non-traceable Author Statement
more info
PubMed 
endothelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of apical/basal cell polarity NAS
Non-traceable Author Statement
more info
PubMed 
fertilization IEA
Inferred from Electronic Annotation
more info
 
keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
retina vasculature morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
vacuolar acidification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
colocalizes_with microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chloride intracellular channel protein 4
Names
chloride intracellular channel 4 like
epididymis secretory sperm binding protein
intracellular chloride ion channel protein p64H1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013943.3NP_039234.1  chloride intracellular channel protein 4

    See identical proteins and their annotated locations for NP_039234.1

    Status: REVIEWED

    Source sequence(s)
    AL662924, BC012444, BQ574968, BQ929781
    Consensus CDS
    CCDS256.1
    UniProtKB/Swiss-Prot
    Q9Y696
    UniProtKB/TrEMBL
    Q6FIC5
    Related
    ENSP00000363500.4, ENST00000374379.8
    Conserved Domains (1) summary
    TIGR00862
    Location:17252
    O-ClC; intracellular chloride channel protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    24745269..24844324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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