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FAM149A family with sequence similarity 149 member A [ Homo sapiens (human) ]

Gene ID: 25854, updated on 24-Jun-2021

Summary

Official Symbol
FAM149Aprovided by HGNC
Official Full Name
family with sequence similarity 149 member Aprovided by HGNC
Primary source
HGNC:HGNC:24527
See related
Ensembl:ENSG00000109794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST119; MSTP119
Expression
Broad expression in kidney (RPKM 4.2), liver (RPKM 2.3) and 22 other tissues See more
Orthologs
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Genomic context

See FAM149A in Genome Data Viewer
Location:
4q35.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (186104704..186175337)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (187025858..187096491)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 64, pseudogene Neighboring gene toll like receptor 3 Neighboring gene ribosomal protein SA pseudogene 70 Neighboring gene LTO1 pseudogene 1 Neighboring gene uncharacterized LOC651430 Neighboring gene cytochrome P450 family 4 subfamily V member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 149, member A (FAM149A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564J102

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006655.3NP_001006656.1  protein FAM149A isoform 1

    See identical proteins and their annotated locations for NP_001006656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AC110771, AF173894, BC142992, BU609191, CD516421
    Consensus CDS
    CCDS34117.1
    UniProtKB/Swiss-Prot
    A5PLN7
    Related
    ENSP00000424380.1, ENST00000514153.5
    Conserved Domains (1) summary
    pfam12516
    Location:266
    DUF3719; Protein of unknown function (DUF3719)
  2. NM_001350178.1NP_001337107.1  protein FAM149A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
    Source sequence(s)
    AK309233, BC142992, BC144411, BU609191, CD516421
    Conserved Domains (1) summary
    pfam12516
    Location:266
    DUF3719; Protein of unknown function (DUF3719)
  3. NM_001350179.1NP_001337108.1  protein FAM149A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
    Source sequence(s)
    AK309233, BC142992, BC144411, BU609191, CD516421, DA159632
    Conserved Domains (1) summary
    pfam12516
    Location:266
    DUF3719; Protein of unknown function (DUF3719)
  4. NM_001367768.3NP_001354697.1  protein FAM149A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses multiple alternate splice sites, and extends the 5' coding region compared to variant 1. It encodes isoform 3 which is longer than isoform 1.
    Source sequence(s)
    AC104070, AC110771
    Related
    ENSP00000348732.5, ENST00000356371.9
  5. NM_001395294.1NP_001382223.1  protein FAM149A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC104070, AC110771
  6. NM_015398.4NP_056213.1  protein FAM149A isoform 1

    See identical proteins and their annotated locations for NP_056213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer isoform (1). Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AC110771, AF173894, BC110816, BU609191
    Consensus CDS
    CCDS34117.1
    UniProtKB/Swiss-Prot
    A5PLN7
    Related
    ENSP00000227065.4, ENST00000227065.8
    Conserved Domains (1) summary
    pfam12516
    Location:266
    DUF3719; Protein of unknown function (DUF3719)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    186104704..186175337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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