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TECPR1 tectonin beta-propeller repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 25851, updated on 21-Dec-2019

Summary

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Official Symbol
TECPR1provided by HGNC
Official Full Name
tectonin beta-propeller repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:22214
See related
Ensembl:ENSG00000205356 MIM:614781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in spleen (RPKM 7.5), brain (RPKM 6.9) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See TECPR1 in Genome Data Viewer
Location:
7q21.3
Exon count:
28
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (98214624..98252235, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (97844755..97881563, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene lemur tyrosine kinase 2 Neighboring gene basic helix-loop-helix family member a15 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 1 Neighboring gene brain protein I3 Neighboring gene RPS3A pseudogene 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The role of Tecpr1 in selective autophagy as a cargo receptor. Ogawa M, et al. Autophagy, 2011 Nov. PMID 21795850
  2. Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners. Kim JH, et al. Autophagy, 2015. PMID 25484072, Free PMC Article
  3. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Chen D, et al. Mol Cell, 2012 Mar 9. PMID 22342342, Free PMC Article
  4. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Ogawa M, et al. Cell Host Microbe, 2011 May 19. PMID 21575909
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198

See all (11) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23419, FLJ90593, DKFZP434B0335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
autophagosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
tectonin beta-propeller repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015395.3 → NP_056210.1  tectonin beta-propeller repeat-containing protein 1

    See identical proteins and their annotated locations for NP_056210.1

    Status: REVIEWED

    Source sequence(s)
    AC091654
    Consensus CDS
    CCDS47648.1
    UniProtKB/Swiss-Prot
    Q7Z6L1
    Related
    ENSP00000404923.2, ENST00000447648.7
    Conserved Domains (6) summary
    smart00694
    Location:888 → 921
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:64 → 125
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:327 → 361
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:604 → 724
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:610 → 716
    PH; PH domain
    pfam06462
    Location:303 → 331
    Hyd_WA; Propeller

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    98214624..98252235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250253.4 → XP_005250310.1  tectonin beta-propeller repeat-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005250310.1

    UniProtKB/Swiss-Prot
    Q7Z6L1
    Conserved Domains (6) summary
    smart00694
    Location:888 → 921
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:64 → 125
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:327 → 361
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:604 → 724
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:610 → 716
    PH; PH domain
    pfam06462
    Location:303 → 331
    Hyd_WA; Propeller

  2. XM_017011937.1 → XP_016867426.1  tectonin beta-propeller repeat-containing protein 1 isoform X2

  3. XM_017011938.1 → XP_016867427.1  tectonin beta-propeller repeat-containing protein 1 isoform X3

RNA

  1. XR_428174.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z6L1.1 GenPept UniProtKB/Swiss-Prot:Q7Z6L1

Gene LinkOut

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