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TECPR1 tectonin beta-propeller repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 25851, updated on 23-Sep-2022

Summary

Official Symbol
TECPR1provided by HGNC
Official Full Name
tectonin beta-propeller repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:22214
See related
Ensembl:ENSG00000205356 MIM:614781; AllianceGenome:HGNC:22214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in spleen (RPKM 7.5), brain (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See TECPR1 in Genome Data Viewer
Location:
7q21.3
Exon count:
27
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (98214624..98252232, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (99444762..99482933, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (97843936..97881544, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 478, pseudogene Neighboring gene lemur tyrosine kinase 2 Neighboring gene basic helix-loop-helix family member a15 Neighboring gene uncharacterized LOC124901706 Neighboring gene Sharpr-MPRA regulatory region 13100 Neighboring gene uncharacterized LOC124901705

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23419, FLJ90593, DKFZP434B0335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of protein-containing complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
tectonin beta-propeller repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015395.3NP_056210.1  tectonin beta-propeller repeat-containing protein 1

    See identical proteins and their annotated locations for NP_056210.1

    Status: REVIEWED

    Source sequence(s)
    AC091654
    Consensus CDS
    CCDS47648.1
    UniProtKB/Swiss-Prot
    Q7Z6L1, Q9UFR6
    Related
    ENSP00000404923.2, ENST00000447648.7
    Conserved Domains (6) summary
    smart00694
    Location:888921
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:64125
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:327361
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:604724
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:610716
    PH; PH domain
    pfam06462
    Location:303331
    Hyd_WA; Propeller

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    98214624..98252232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420119.1XP_047276075.1  tectonin beta-propeller repeat-containing protein 1 isoform X2

  2. XM_005250253.5XP_005250310.1  tectonin beta-propeller repeat-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005250310.1

    UniProtKB/Swiss-Prot
    Q7Z6L1, Q9UFR6
    Conserved Domains (6) summary
    smart00694
    Location:888921
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:64125
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:327361
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:604724
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:610716
    PH; PH domain
    pfam06462
    Location:303331
    Hyd_WA; Propeller
  3. XM_017011937.2XP_016867426.1  tectonin beta-propeller repeat-containing protein 1 isoform X2

RNA

  1. XR_428174.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    99444762..99482933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)