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COG4 component of oligomeric golgi complex 4 [ Homo sapiens (human) ]

Gene ID: 25839, updated on 19-Nov-2022

Summary

Official Symbol
COG4provided by HGNC
Official Full Name
component of oligomeric golgi complex 4provided by HGNC
Primary source
HGNC:HGNC:18620
See related
Ensembl:ENSG00000103051 MIM:606976; AllianceGenome:HGNC:18620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COD1; CDG2J; SWILS
Summary
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in testis (RPKM 19.4), skin (RPKM 14.3) and 25 other tissues See more
Orthologs
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Genomic context

See COG4 in Genome Data Viewer
Location:
16q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70480567..70523554, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (76291598..76334735, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70514470..70557457, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903708 Neighboring gene fucose kinase Neighboring gene small nucleolar RNA, C/D box 111B Neighboring gene splicing factor 3b subunit 3 Neighboring gene small nucleolar RNA, C/D box 111

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of component of oligomeric golgi complex 4 (COG4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586E1519

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IC
Inferred by Curator
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Golgi transport complex IC
Inferred by Curator
more info
PubMed 
part_of Golgi transport complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
conserved oligomeric Golgi complex subunit 4
Names
COG complex subunit 4
complexed with Dor1p
conserved oligomeric Golgi complex protein 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027529.1 RefSeqGene

    Range
    5001..47984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195139.2NP_001182068.2  conserved oligomeric Golgi complex subunit 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC106804, AK096557, AL050101, AU125729, BP282697
    Consensus CDS
    CCDS73909.2
    UniProtKB/TrEMBL
    A0A6I8PIQ6
    Related
    ENSP00000501405.1, ENST00000674443.1
  2. NM_001365426.1NP_001352355.1  conserved oligomeric Golgi complex subunit 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC106804
  3. NM_015386.3NP_056201.2  conserved oligomeric Golgi complex subunit 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AK096557, AL050101, AU125729, BP282697
    Consensus CDS
    CCDS10892.2
    UniProtKB/Swiss-Prot
    Q9H9E3
    UniProtKB/TrEMBL
    J3KNI1, Q8N8L9
    Related
    ENSP00000315775.5, ENST00000323786.10
    Conserved Domains (2) summary
    pfam08318
    Location:192501
    COG4; COG4 transport protein
    cl19885
    Location:551788
    Sec6; Exocyst complex component Sec6

RNA

  1. NR_158212.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC106804
    Related
    ENST00000703108.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    70480567..70523554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    76291598..76334735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145818.1: Suppressed sequence

    Description
    NM_145818.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.