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COG4 component of oligomeric golgi complex 4 [ Homo sapiens (human) ]

Gene ID: 25839, updated on 20-Mar-2020

Summary

Official Symbol
COG4provided by HGNC
Official Full Name
component of oligomeric golgi complex 4provided by HGNC
Primary source
HGNC:HGNC:18620
See related
Ensembl:ENSG00000103051 MIM:606976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COD1; CDG2J; SWILS
Summary
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in testis (RPKM 19.4), skin (RPKM 14.3) and 25 other tissues See more
Orthologs

Genomic context

See COG4 in Genome Data Viewer
Location:
16q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (70480567..70523554, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70514472..70557457, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 23, pseudogene Neighboring gene fucose kinase Neighboring gene small nucleolar RNA, C/D box 111B Neighboring gene splicing factor 3b subunit 3 Neighboring gene small nucleolar RNA, C/D box 111

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of component of oligomeric golgi complex 4 (COG4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586E1519

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi vesicle prefusion complex stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi vesicle prefusion complex stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi transport complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
conserved oligomeric Golgi complex subunit 4
Names
COG complex subunit 4
complexed with Dor1p
conserved oligomeric Golgi complex protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027529.1 RefSeqGene

    Range
    5001..47984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195139.2NP_001182068.2  conserved oligomeric Golgi complex subunit 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC106804, AK096557, AL050101, AU125729, BP282697
    Consensus CDS
    CCDS73909.1
    Related
    ENSP00000377236.5, ENST00000393612.8
  2. NM_001365426.1NP_001352355.1  conserved oligomeric Golgi complex subunit 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC106804
  3. NM_015386.3NP_056201.2  conserved oligomeric Golgi complex subunit 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AK096557, AL050101, AU125729, BP282697
    Consensus CDS
    CCDS10892.2
    UniProtKB/Swiss-Prot
    Q9H9E3
    UniProtKB/TrEMBL
    J3KNI1, Q8N8L9
    Related
    ENSP00000315775.5, ENST00000323786.10
    Conserved Domains (2) summary
    pfam08318
    Location:192501
    COG4; COG4 transport protein
    cl19885
    Location:551788
    Sec6; Exocyst complex component Sec6

RNA

  1. NR_158212.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC106804
    Related
    ENST00000564415.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    70480567..70523554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450224.1XP_024305992.1  conserved oligomeric Golgi complex subunit 4 isoform X2

    Related
    ENST00000530314.5
    Conserved Domains (3) summary
    pfam04437
    Location:263449
    RINT1_TIP1; RINT-1 / TIP-1 family
    pfam07393
    Location:358458
    Sec10; Exocyst complex component Sec10
    pfam08318
    Location:20195
    COG4; COG4 transport protein

RNA

  1. XR_001751889.1 RNA Sequence

  2. XR_933267.1 RNA Sequence

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