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POU2F3 POU class 2 homeobox 3 [ Homo sapiens (human) ]

Gene ID: 25833, updated on 7-Dec-2018

Summary

Official Symbol
POU2F3provided by HGNC
Official Full Name
POU class 2 homeobox 3provided by HGNC
Primary source
HGNC:HGNC:19864
See related
Ensembl:ENSG00000137709 MIM:607394
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLA1; OCT11; PLA-1; Epoc-1; OCT-11; OTF-11; Skn-1a
Summary
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Expression
Biased expression in skin (RPKM 16.5) and lung (RPKM 0.4) See more
Orthologs

Genomic context

See POU2F3 in Genome Data Viewer
Location:
11q23.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (120236640..120319944)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (120107349..120190653)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369530 Neighboring gene HNF4 motif-containing MPRA enhancer 139 Neighboring gene out at first homolog Neighboring gene uncharacterized LOC649133 Neighboring gene uncharacterized LOC105369531 Neighboring gene transmembrane protein 136 Neighboring gene Rho guanine nucleotide exchange factor 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40063, MGC126698

General protein information

Preferred Names
POU domain, class 2, transcription factor 3
Names
POU domain transcription factor OCT11a
octamer-binding protein 11
octamer-binding transcription factor 11
transcription factor PLA-1
transcription factor Skn-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030035.1 RefSeqGene

    Range
    5001..88305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001244682.1NP_001231611.1  POU domain, class 2, transcription factor 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK302212, AP000679, AP001150, CU451853
    Consensus CDS
    CCDS58190.1
    UniProtKB/Swiss-Prot
    Q9UKI9
    Related
    ENSP00000260264.4, ENST00000260264.8
    Conserved Domains (2) summary
    smart00352
    Location:185259
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:286339
    Homeobox; Homeobox domain
  2. NM_014352.4NP_055167.2  POU domain, class 2, transcription factor 3 isoform 1

    See identical proteins and their annotated locations for NP_055167.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK291993, AP000679, AP001150, BC101649
    Consensus CDS
    CCDS8431.1
    UniProtKB/Swiss-Prot
    Q9UKI9
    Related
    ENSP00000441687.2, ENST00000543440.6
    Conserved Domains (2) summary
    smart00352
    Location:183257
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284337
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    120236640..120319944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017487.1XP_016872976.1  POU domain, class 2, transcription factor 3 isoform X4

  2. XM_011542739.2XP_011541041.1  POU domain, class 2, transcription factor 3 isoform X1

    See identical proteins and their annotated locations for XP_011541041.1

    UniProtKB/Swiss-Prot
    Q9UKI9
    Conserved Domains (2) summary
    smart00352
    Location:179253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:280333
    Homeobox; Homeobox domain
  3. XM_011542740.2XP_011541042.1  POU domain, class 2, transcription factor 3 isoform X1

    See identical proteins and their annotated locations for XP_011541042.1

    UniProtKB/Swiss-Prot
    Q9UKI9
    Conserved Domains (2) summary
    smart00352
    Location:179253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:280333
    Homeobox; Homeobox domain
  4. XM_011542742.3XP_011541044.1  POU domain, class 2, transcription factor 3 isoform X3

    See identical proteins and their annotated locations for XP_011541044.1

    Conserved Domains (2) summary
    smart00352
    Location:150224
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:251304
    Homeobox; Homeobox domain
  5. XM_011542741.3XP_011541043.1  POU domain, class 2, transcription factor 3 isoform X3

    See identical proteins and their annotated locations for XP_011541043.1

    Conserved Domains (2) summary
    smart00352
    Location:150224
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:251304
    Homeobox; Homeobox domain
  6. XM_024448424.1XP_024304192.1  POU domain, class 2, transcription factor 3 isoform X2

    Conserved Domains (2) summary
    smart00352
    Location:171245
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:272325
    Homeobox; Homeobox domain
  7. XM_011542743.2XP_011541045.1  POU domain, class 2, transcription factor 3 isoform X3

    See identical proteins and their annotated locations for XP_011541045.1

    Conserved Domains (2) summary
    smart00352
    Location:150224
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:251304
    Homeobox; Homeobox domain
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