U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 25820, updated on 6-Oct-2024

Summary

Official Symbol
ARIH1provided by HGNC
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:689
See related
Ensembl:ENSG00000166233 MIM:605624; AllianceGenome:HGNC:689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARI; HARI; HHARI; UBCH7BP
Summary
Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 22.0), thyroid (RPKM 13.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ARIH1 in Genome Data Viewer
Location:
15q24.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72474330..72602987)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70291593..70420271)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72766671..72895328)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene TMEM202 antisense RNA 1 Neighboring gene transmembrane protein 202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:72743763-72744262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9722 Neighboring gene PHB1 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9723 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:72766566-72766762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6625 Neighboring gene MPRA-validated peak2380 silencer Neighboring gene SWI5 recombination repair homolog (yeast) pseudogene Neighboring gene microRNA 630 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:72902139-72902639 Neighboring gene golgin A6 family member A pseudogene Neighboring gene long intergenic non-protein coding RNA 2259

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ20329, FLJ93118, DKFZp686O13120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in PKR/eIFalpha signaling TAS
Traceable Author Statement
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
 
NOT part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Cul4A-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in Lewy body IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ARIH1
Names
ARI-1
H7-AP2
MOP-6
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1
ariadne, Drosophila, homolog of
monocyte protein 6
protein ariadne-1 homolog
ubcH7-binding protein
ubcM4-interacting protein
ubiquitin-conjugating enzyme E2-binding protein 1
NP_005735.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005744.5NP_005735.2  E3 ubiquitin-protein ligase ARIH1

    See identical proteins and their annotated locations for NP_005735.2

    Status: VALIDATED

    Source sequence(s)
    AC079322, AC100827
    Consensus CDS
    CCDS10244.1
    UniProtKB/Swiss-Prot
    B2R6U3, O76026, Q9H3T6, Q9UEN0, Q9UP39, Q9Y4X5
    Related
    ENSP00000369217.4, ENST00000379887.9
    Conserved Domains (3) summary
    smart00647
    Location:257317
    IBR; In Between Ring fingers
    cd16626
    Location:185242
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:339379
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    72474330..72602987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    70291593..70420271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)