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ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 25820, updated on 9-Dec-2018

Summary

Official Symbol
ARIH1provided by HGNC
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:689
See related
Ensembl:ENSG00000166233 MIM:605624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARI; HARI; HHARI; UBCH7BP
Expression
Ubiquitous expression in testis (RPKM 22.0), thyroid (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See ARIH1 in Genome Data Viewer
Location:
15q24.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (72474326..72586555)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72766667..72878904)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene TMEM202 antisense RNA 1 Neighboring gene uncharacterized LOC107983949 Neighboring gene prohibitin pseudogene 20 Neighboring gene uncharacterized LOC112268158 Neighboring gene microRNA 630 Neighboring gene SWI5 recombination repair homolog (yeast) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20329, FLJ93118, DKFZp686O13120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-like protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Cajal body IEA
Inferred from Electronic Annotation
more info
 
NOT colocalizes_with Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Cul4A-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
Lewy body IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin ligase complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ARIH1
Names
ARI-1
H7-AP2
MOP-6
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1
ariadne, Drosophila, homolog of
monocyte protein 6
protein ariadne-1 homolog
ubcH7-binding protein
ubcM4-interacting protein
ubiquitin-conjugating enzyme E2-binding protein 1
NP_005735.2
XP_011519740.1
XP_011519741.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005744.4NP_005735.2  E3 ubiquitin-protein ligase ARIH1

    See identical proteins and their annotated locations for NP_005735.2

    Status: VALIDATED

    Source sequence(s)
    AC079322, AC100827
    Consensus CDS
    CCDS10244.1
    UniProtKB/Swiss-Prot
    Q9Y4X5
    Related
    ENSP00000369217.4, ENST00000379887.8
    Conserved Domains (3) summary
    smart00647
    Location:257317
    IBR; In Between Ring fingers
    pfam01485
    Location:339379
    IBR; IBR domain, a half RING-finger domain
    cd16626
    Location:185242
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    72474326..72586555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521438.3XP_011519740.1  E3 ubiquitin-protein ligase ARIH1 isoform X1

    Conserved Domains (2) summary
    smart00647
    Location:198258
    IBR; In Between Ring fingers
    pfam01485
    Location:280320
    IBR; IBR domain, a half RING-finger domain
  2. XM_011521439.3XP_011519741.1  E3 ubiquitin-protein ligase ARIH1 isoform X2

    See identical proteins and their annotated locations for XP_011519741.1

    Conserved Domains (3) summary
    smart00647
    Location:165225
    IBR; In Between Ring fingers
    pfam01485
    Location:247287
    IBR; IBR domain, a half RING-finger domain
    cd16626
    Location:93150
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
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