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Arih1 ariadne RBR E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 23806, updated on 27-Dec-2022

Summary

Official Symbol
Arih1provided by MGI
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 1provided by MGI
Primary source
MGI:MGI:1344363
See related
Ensembl:ENSMUSG00000025234 AllianceGenome:MGI:1344363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ari; Ari1; Hari; Hhari; Uip77; Ubch7bp
Summary
Predicted to enable enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in Lewy body and nuclear body. Predicted to be part of Cul3-RING ubiquitin ligase complex; Cul4A-RING E3 ubiquitin ligase complex; and SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in hippocampus. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.4), testis adult (RPKM 8.9) and 28 other tissues See more
Orthologs
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Genomic context

See Arih1 in Genome Data Viewer
Location:
9; 9 B
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59295837..59395469, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59388554..59488186, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ADP-dependent glucokinase Neighboring gene Bardet-Biedl syndrome 4 (human) Neighboring gene ribosomal protein S11, pseudogene 1 Neighboring gene predicted gene, 20199 Neighboring gene predicted gene, 33180 Neighboring gene transmembrane protein 202 Neighboring gene hexosaminidase A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in Lewy body ISO
Inferred from Sequence Orthology
more info
 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ARIH1
Names
ARI-1
RING-type E3 ubiquitin transferase ARIH1
UbcH7-binding protein
UbcM4-interacting protein 77
ariadne 1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1
protein ariadne-1 homolog
ubiquitin-conjugating enzyme E2-binding protein 1
NP_064311.2
XP_006511203.1
XP_006511204.1
XP_011241041.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019927.2NP_064311.2  E3 ubiquitin-protein ligase ARIH1

    See identical proteins and their annotated locations for NP_064311.2

    Status: VALIDATED

    Source sequence(s)
    AJ130977, AK032640, AK047617, AW125831, CA328699, CJ176800, CK633971, CV555932
    Consensus CDS
    CCDS52817.1
    UniProtKB/Swiss-Prot
    Q8CFJ4, Q9Z1K5
    UniProtKB/TrEMBL
    A0A8C6IGQ4
    Related
    ENSMUSP00000126531.2, ENSMUST00000171975.8
    Conserved Domains (3) summary
    smart00647
    Location:255315
    IBR; In Between Ring fingers
    cd16626
    Location:183240
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:337377
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    59295837..59395469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511140.4XP_006511203.1  E3 ubiquitin-protein ligase ARIH1 isoform X1

    Conserved Domains (3) summary
    smart00647
    Location:196256
    IBR; In Between Ring fingers
    cd16626
    Location:124181
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:278318
    IBR; IBR domain, a half RING-finger domain
  2. XM_006511141.3XP_006511204.1  E3 ubiquitin-protein ligase ARIH1 isoform X3

    UniProtKB/TrEMBL
    A0A6P7R8P5
    Conserved Domains (3) summary
    smart00647
    Location:165225
    IBR; In Between Ring fingers
    cd16626
    Location:93150
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:247287
    IBR; IBR domain, a half RING-finger domain
  3. XM_011242739.3XP_011241041.1  E3 ubiquitin-protein ligase ARIH1 isoform X2

    Conserved Domains (3) summary
    smart00647
    Location:173233
    IBR; In Between Ring fingers
    cd16626
    Location:101158
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:255295
    IBR; IBR domain, a half RING-finger domain

RNA

  1. XR_004935434.1 RNA Sequence