KLK5 kallikrein related peptidase 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLK5provided by HGNC
Official Full Name: kallikrein related peptidase 5provided by HGNC
Primary source: HGNC:HGNC:6366
See related: Ensembl:ENSG00000167754 MIM:605643; AllianceGenome:HGNC:6366
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SCTE; KLKL2; KLK-L2
Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression: Biased expression in skin (RPKM 70.7), lung (RPKM 6.1) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.41

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (50943303..50953038, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (54031364..54041157, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (51446559..51456294, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation.
Title: The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation.
MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5.
Title: MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5.
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
Title: Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
Title: KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.
Title: Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.
Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
Title: Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition.
Title: Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition.
Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium.
Title: Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium.
Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
Title: Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
Title: PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	EXP Inferred from Experiment more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in amelogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cornification	TAS Traceable Author Statement more info
involved_in epidermis development	TAS Traceable Author Statement more info	PubMed
involved_in extracellular matrix disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in epidermal lamellar body	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-5

Names: kallikrein-like protein 2; stratum corneum tryptic enzyme

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077491.2 → NP_001070959.1 kallikrein-5 preproprotein

See identical proteins and their annotated locations for NP_001070959.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.

Source sequence(s)

AY279381, AY359010

Consensus CDS

CCDS12810.1

UniProtKB/Swiss-Prot

A0A024R4G4, Q9HBG8, Q9Y337

UniProtKB/TrEMBL

Q53F68

Related

ENSP00000375685.1, ENST00000391809.6

Conserved Domains (1) summary

smart00020
Location:66 → 285

Tryp_SPc; Trypsin-like serine protease
NM_001077492.2 → NP_001070960.1 kallikrein-5 preproprotein

See identical proteins and their annotated locations for NP_001070960.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.

Source sequence(s)

AY359010

Consensus CDS

CCDS12810.1

UniProtKB/Swiss-Prot

A0A024R4G4, Q9HBG8, Q9Y337

UniProtKB/TrEMBL

Q53F68

Related

ENSP00000471966.1, ENST00000593428.5

Conserved Domains (1) summary

smart00020
Location:66 → 285

Tryp_SPc; Trypsin-like serine protease
NM_012427.5 → NP_036559.1 kallikrein-5 preproprotein

See identical proteins and their annotated locations for NP_036559.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.

Source sequence(s)

AY359010

Consensus CDS

CCDS12810.1

UniProtKB/Swiss-Prot

A0A024R4G4, Q9HBG8, Q9Y337

UniProtKB/TrEMBL

Q53F68

Related

ENSP00000337733.2, ENST00000336334.8

Conserved Domains (1) summary

smart00020
Location:66 → 285

Tryp_SPc; Trypsin-like serine protease