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KLK5 kallikrein related peptidase 5 [ Homo sapiens (human) ]

Gene ID: 25818, updated on 2-Nov-2024

Summary

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Official Symbol
KLK5provided by HGNC
Official Full Name
kallikrein related peptidase 5provided by HGNC
Primary source
HGNC:HGNC:6366
See related
Ensembl:ENSG00000167754 MIM:605643; AllianceGenome:HGNC:6366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCTE; KLKL2; KLK-L2
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 70.7), lung (RPKM 6.1) and 1 other tissue See more
Orthologs
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Genomic context

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See KLK5 in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (50943303..50953038, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54031364..54041157, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51446559..51456294, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 4 Neighboring gene peptidylprolyl isomerase A pseudogene 59 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51442294-51442457 Neighboring gene uncharacterized LOC105372442 Neighboring gene kallikrein related peptidase 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51486908-51487462 Neighboring gene kallikrein related peptidase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria. Grzanka A, et al. J Biol Regul Homeost Agents, 2017 Apr-Jun. PMID 28685545
  2. Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival. Dorn J, et al. Ann Oncol, 2011 Aug. PMID 21273346
  3. Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response. Bandiera E, et al. Int J Gynecol Cancer, 2009 Aug. PMID 19820362
  4. Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer. Bayani J, et al. Mol Oncol, 2008 Oct. PMID 19383346, Free PMC Article
  5. The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. Pampalakis G, et al. Oncotarget, 2014 May 15. PMID 24158494, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation.
    Title: The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation.
  2. MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5.
    Title: MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5.
  3. Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
    Title: Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
  4. KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
    Title: KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
  5. Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.
    Title: Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.
  6. Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
    Title: Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
  7. Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition.
    Title: Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition.
  8. Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium.
    Title: Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium.
  9. Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
    Title: Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
  10. PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
    Title: PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity EXP
Inferred from Experiment
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables serine-type peptidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in amelogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cornification TAS
Traceable Author Statement
more info
  
involved_in epidermis development TAS
Traceable Author Statement
more info
 PubMed 
involved_in extracellular matrix disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of antibacterial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in epidermal lamellar body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kallikrein-5
Names
kallikrein-like protein 2
stratum corneum tryptic enzyme

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077491.2 → NP_001070959.1  kallikrein-5 preproprotein

    See identical proteins and their annotated locations for NP_001070959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AY279381, AY359010
    Consensus CDS
    CCDS12810.1
    UniProtKB/Swiss-Prot
    A0A024R4G4, Q9HBG8, Q9Y337
    UniProtKB/TrEMBL
    Q53F68
    Related
    ENSP00000375685.1, ENST00000391809.6
    Conserved Domains (1) summary
    smart00020
    Location:66 → 285
    Tryp_SPc; Trypsin-like serine protease

  2. NM_001077492.2 → NP_001070960.1  kallikrein-5 preproprotein

    See identical proteins and their annotated locations for NP_001070960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AY359010
    Consensus CDS
    CCDS12810.1
    UniProtKB/Swiss-Prot
    A0A024R4G4, Q9HBG8, Q9Y337
    UniProtKB/TrEMBL
    Q53F68
    Related
    ENSP00000471966.1, ENST00000593428.5
    Conserved Domains (1) summary
    smart00020
    Location:66 → 285
    Tryp_SPc; Trypsin-like serine protease

  3. NM_012427.5 → NP_036559.1  kallikrein-5 preproprotein

    See identical proteins and their annotated locations for NP_036559.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AY359010
    Consensus CDS
    CCDS12810.1
    UniProtKB/Swiss-Prot
    A0A024R4G4, Q9HBG8, Q9Y337
    UniProtKB/TrEMBL
    Q53F68
    Related
    ENSP00000337733.2, ENST00000336334.8
    Conserved Domains (1) summary
    smart00020
    Location:66 → 285
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    50943303..50953038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526702.2 → XP_011525004.1  kallikrein-5 isoform X1

    See identical proteins and their annotated locations for XP_011525004.1

    UniProtKB/Swiss-Prot
    A0A024R4G4, Q9HBG8, Q9Y337
    UniProtKB/TrEMBL
    Q53F68
    Conserved Domains (1) summary
    smart00020
    Location:66 → 285
    Tryp_SPc; Trypsin-like serine protease

  2. XM_011526703.3 → XP_011525005.1  kallikrein-5 isoform X1

    See identical proteins and their annotated locations for XP_011525005.1

    UniProtKB/Swiss-Prot
    A0A024R4G4, Q9HBG8, Q9Y337
    UniProtKB/TrEMBL
    Q53F68
    Conserved Domains (1) summary
    smart00020
    Location:66 → 285
    Tryp_SPc; Trypsin-like serine protease

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54031364..54041157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320472.1 → XP_054176447.1  kallikrein-5 isoform X1

    UniProtKB/Swiss-Prot
    A0A024R4G4, Q9HBG8, Q9Y337

  2. XM_054320473.1 → XP_054176448.1  kallikrein-5 isoform X1

    UniProtKB/Swiss-Prot
    A0A024R4G4, Q9HBG8, Q9Y337
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y337.3 GenPept UniProtKB/Swiss-Prot:Q9Y337

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