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KLK5 kallikrein related peptidase 5 [ Homo sapiens (human) ]

Gene ID: 25818, updated on 20-Jan-2019

Summary

Official Symbol
KLK5provided by HGNC
Official Full Name
kallikrein related peptidase 5provided by HGNC
Primary source
HGNC:HGNC:6366
See related
Ensembl:ENSG00000167754 MIM:605643
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCTE; KLKL2; KLK-L2
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 70.7), lung (RPKM 6.1) and 1 other tissue See more
Orthologs

Genomic context

See KLK5 in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (50943299..50953088, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51446559..51456344, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 4 Neighboring gene peptidylprolyl isomerase A pseudogene 59 Neighboring gene uncharacterized LOC105372442 Neighboring gene kallikrein related peptidase 6 Neighboring gene kallikrein related peptidase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Formation of the cornified envelope, organism-specific biosystem (from REACTOME)
    Formation of the cornified envelope, organism-specific biosystemAs keratinocytes progress towards the upper epidermis, they undergo a unique process of cell death termed cornification (Eckhart et al. 2013). This involves the crosslinking of keratinocyte proteins ...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity TAS
Traceable Author Statement
more info
 
peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
amelogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cornification TAS
Traceable Author Statement
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
extracellular matrix disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of antibacterial peptide production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of antibacterial peptide production IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
epidermal lamellar body IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kallikrein-5
Names
kallikrein-like protein 2
stratum corneum tryptic enzyme

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077491.1NP_001070959.1  kallikrein-5 preproprotein

    See identical proteins and their annotated locations for NP_001070959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AY279381, AY359010
    Consensus CDS
    CCDS12810.1
    UniProtKB/Swiss-Prot
    Q9Y337
    Related
    ENSP00000375685.1, ENST00000391809.6
    Conserved Domains (1) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease
  2. NM_001077492.1NP_001070960.1  kallikrein-5 preproprotein

    See identical proteins and their annotated locations for NP_001070960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AY359010
    Consensus CDS
    CCDS12810.1
    UniProtKB/Swiss-Prot
    Q9Y337
    Related
    ENSP00000471966.1, ENST00000593428.5
    Conserved Domains (1) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease
  3. NM_012427.5NP_036559.1  kallikrein-5 preproprotein

    See identical proteins and their annotated locations for NP_036559.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AY359010
    Consensus CDS
    CCDS12810.1
    UniProtKB/Swiss-Prot
    Q9Y337
    Related
    ENSP00000337733.2, ENST00000336334.7
    Conserved Domains (1) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    50943299..50953088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526703.2XP_011525005.1  kallikrein-5 isoform X1

    See identical proteins and their annotated locations for XP_011525005.1

    UniProtKB/Swiss-Prot
    Q9Y337
    Conserved Domains (1) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease
  2. XM_011526702.1XP_011525004.1  kallikrein-5 isoform X1

    See identical proteins and their annotated locations for XP_011525004.1

    UniProtKB/Swiss-Prot
    Q9Y337
    Conserved Domains (1) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease
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