U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

QPCT glutaminyl-peptide cyclotransferase [ Homo sapiens (human) ]

Gene ID: 25797, updated on 7-Apr-2025

Summary

Official Symbol
QPCTprovided by HGNC
Official Full Name
glutaminyl-peptide cyclotransferaseprovided by HGNC
Primary source
HGNC:HGNC:9753
See related
Ensembl:ENSG00000115828 MIM:607065; AllianceGenome:HGNC:9753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QC; GCT; sQC
Summary
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 75.9), bone marrow (RPKM 17.6) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See QPCT in Genome Data Viewer
Location:
2p22.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (37344630..37373322)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (37351621..37380410)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37571773..37600465)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11356 Neighboring gene PRKD3 divergent transcript Neighboring gene RNA, U6 small nuclear 939, pseudogene Neighboring gene uncharacterized LOC124907754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11357 Neighboring gene uncharacterized LOC107985868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11358 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:37603562-37604761 Neighboring gene MPRA-validated peak3659 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15583 Neighboring gene VISTA enhancer hs1480 Neighboring gene RNA, U6 small nuclear 1116, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog
Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutaminyl-peptide cyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutaminyl-peptide cyclotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutaminyl-peptide cyclotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in specific granule lumen TAS
Traceable Author Statement
more info
 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glutaminyl-peptide cyclotransferase
Names
EC
glutaminyl cyclase
glutaminyl-tRNA cyclotransferase
glutamyl cyclase
NP_036545.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012413.4NP_036545.1  glutaminyl-peptide cyclotransferase precursor

    See identical proteins and their annotated locations for NP_036545.1

    Status: REVIEWED

    Source sequence(s)
    BC020456, BC047756, BF970452, BI755122
    Consensus CDS
    CCDS1790.1
    UniProtKB/Swiss-Prot
    Q16769, Q16770, Q3KRG6, Q53TR4
    Related
    ENSP00000344829.3, ENST00000338415.8
    Conserved Domains (1) summary
    cd03880
    Location:51358
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    37344630..37373322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    37351621..37380410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)