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QPCT glutaminyl-peptide cyclotransferase [ Homo sapiens (human) ]

Gene ID: 25797, updated on 7-Dec-2018

Summary

Official Symbol
QPCTprovided by HGNC
Official Full Name
glutaminyl-peptide cyclotransferaseprovided by HGNC
Primary source
HGNC:HGNC:9753
See related
Ensembl:ENSG00000115828 MIM:607065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QC; GCT; sQC
Summary
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 75.9), bone marrow (RPKM 17.6) and 13 other tissues See more
Orthologs

Genomic context

See QPCT in Genome Data Viewer
Location:
2p22.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (37344610..37373322)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37571742..37600465)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929542 Neighboring gene RNA, U6 small nuclear 939, pseudogene Neighboring gene uncharacterized LOC107985868 Neighboring gene VISTA enhancer hs1480

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
NHGRI GWA Catalog

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutaminyl-peptide cyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutaminyl-peptide cyclotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glutaminyl-peptide cyclotransferase
Names
EC
glutaminyl cyclase
glutaminyl-tRNA cyclotransferase
glutamyl cyclase
NP_036545.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012413.4NP_036545.1  glutaminyl-peptide cyclotransferase precursor

    See identical proteins and their annotated locations for NP_036545.1

    Status: REVIEWED

    Source sequence(s)
    BC020456, BC047756, BF970452, BI755122
    Consensus CDS
    CCDS1790.1
    UniProtKB/Swiss-Prot
    Q16769
    Related
    ENSP00000344829.3, ENST00000338415.7
    Conserved Domains (1) summary
    cd03880
    Location:51358
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    37344610..37373322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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