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Qpct glutaminyl-peptide cyclotransferase (glutaminyl cyclase) [ Mus musculus (house mouse) ]

Gene ID: 70536, updated on 8-Mar-2025

Summary

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Official Symbol
Qpctprovided by MGI
Official Full Name
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)provided by MGI
Primary source
MGI:MGI:1917786
See related
Ensembl:ENSMUSG00000024084 AllianceGenome:MGI:1917786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730422A13Rik
Summary
Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; central nervous system; future brain; integumental system; and placenta. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase). [provided by Alliance of Genome Resources, Mar 2025]
Expression
Broad expression in liver E18 (RPKM 17.4), testis adult (RPKM 10.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Qpct in Genome Data Viewer
Location:
17 E3; 17 49.83 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79359335..79397807)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (79051906..79090378)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5629 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene protein kinase D3 Neighboring gene predicted gene, 41622 Neighboring gene STARR-seq mESC enhancer starr_43275 Neighboring gene STARR-seq mESC enhancer starr_43276 Neighboring gene STARR-seq mESC enhancer starr_43277 Neighboring gene STARR-seq mESC enhancer starr_43278 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_43280 Neighboring gene CDC42 effector protein 3 Neighboring gene predicted gene, 17315

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct. Guo J, et al. Mol Cells, 2015 Oct. PMID 26447138, Free PMC Article
  2. Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC. Höfling C, et al. Int J Dev Neurosci, 2014 Aug. PMID 24886834
  3. Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase. Schilling S, et al. Biochemistry, 2005 Oct 11. PMID 16201766
  4. Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development. Schilling S, et al. J Biol Chem, 2011 Apr 22. PMID 21330373, Free PMC Article
  5. Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain. Hartlage-Rübsamen M, et al. Int J Dev Neurosci, 2009 Dec. PMID 19699792

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.
    Title: Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct.
  2. co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits
    Title: Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes.
  3. This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC in defined brain regions of different inbred and outbred mouse strains
    Title: Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC.
  4. This study presents a first comparison of two mammalian QCs (mouse and human)containing typical, conserved post-translational modifications.
    Title: Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.
  5. Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism
    Title: Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
  6. QC is crucial for modulating AbetapE3-42 levels in vivo and prove on a genetic base the concept that reduction of QC activity is a promising new therapeutic approach for AD.
    Title: Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
  7. Murine isoQC proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.
    Title: Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.
  8. Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.
    Title: Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.
  9. The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1, cathepsin B, and glutaminyl cyclase.
    Title: Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain.
  10. QC is a zinc-dependent catalyst
    Title: Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutaminyl-peptide cyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-peptide cyclotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutaminyl-peptide cyclotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutaminyl-peptide cyclotransferase
Names
QC
glutaminyl cyclase
glutaminyl-tRNA cyclotransferase
NP_001303658.1
NP_081731.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316729.1 → NP_001303658.1  glutaminyl-peptide cyclotransferase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK045974, AK148394, CK624808
    Consensus CDS
    CCDS89158.1
    UniProtKB/Swiss-Prot
    Q8BH20, Q8VE07, Q9CYK2
    UniProtKB/TrEMBL
    A0A3B2W7G1
    Related
    ENSMUSP00000156493.2, ENSMUST00000233916.2
    Conserved Domains (1) summary
    cd03880
    Location:41 → 310
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

  2. NM_027455.3 → NP_081731.1  glutaminyl-peptide cyclotransferase isoform 1 precursor

    See identical proteins and their annotated locations for NP_081731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK045974, AK148394
    Consensus CDS
    CCDS28983.1
    UniProtKB/Swiss-Prot
    Q8BH20, Q8VE07, Q9CYK2
    UniProtKB/TrEMBL
    A0A0R4J0G6
    Related
    ENSMUSP00000038732.5, ENSMUST00000040789.6
    Conserved Domains (1) summary
    cd03880
    Location:60 → 359
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    79359335..79397807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYK2.2 GenPept UniProtKB/Swiss-Prot:Q9CYK2

Gene LinkOut

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