U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CIZ1 CDKN1A interacting zinc finger protein 1 [ Homo sapiens (human) ]

Gene ID: 25792, updated on 17-Sep-2022

Summary

Official Symbol
CIZ1provided by HGNC
Official Full Name
CDKN1A interacting zinc finger protein 1provided by HGNC
Primary source
HGNC:HGNC:16744
See related
Ensembl:ENSG00000148337 MIM:611420; AllianceGenome:HGNC:16744
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NP94; LSFR1; ZNF356
Summary
The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in ovary (RPKM 30.0), testis (RPKM 29.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CIZ1 in Genome Data Viewer
Location:
9q34.11
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128166065..128204222, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140373145..140411302, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130928344..130966501, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene lipocalin 2 Neighboring gene bublin coiled coil protein Neighboring gene Sharpr-MPRA regulatory region 9989 Neighboring gene dynamin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr9:130980103-130981059 and GRCh37_chr9:130981060-130982015 Neighboring gene microRNA 199b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in maintenance of protein location in nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cip1-interacting zinc finger protein
Names
nuclear protein NP94
zinc finger protein 356

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032983.1 RefSeqGene

    Range
    17812..43319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001131015.2NP_001124487.1  cip1-interacting zinc finger protein isoform 2

    See identical proteins and their annotated locations for NP_001124487.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (2) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 5.
    Source sequence(s)
    AK023978, BC004119, BC021163
    Consensus CDS
    CCDS48034.1
    UniProtKB/Swiss-Prot
    Q9ULV3
    UniProtKB/TrEMBL
    Q9BTG3
    Related
    ENSP00000362039.3, ENST00000372948.7
    Conserved Domains (4) summary
    smart00451
    Location:536565
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:600620
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:630654
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl26464
    Location:117426
    Atrophin-1; Atrophin-1 family
  2. NM_001131016.2NP_001124488.1  cip1-interacting zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_001124488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate exon in place of the first exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5. Variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AK292713, AK303636, BC021163
    Consensus CDS
    CCDS6894.1
    UniProtKB/Swiss-Prot
    Q9ULV3, Q9Y3G0
    UniProtKB/TrEMBL
    A0A024R885
    Related
    ENSP00000362029.5, ENST00000372938.10
    Conserved Domains (4) summary
    smart00451
    Location:592621
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:656676
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:686710
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl26464
    Location:129482
    Atrophin-1; Atrophin-1 family
  3. NM_001131017.2NP_001124489.1  cip1-interacting zinc finger protein isoform 3

    See identical proteins and their annotated locations for NP_001124489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (3) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 5.
    Source sequence(s)
    AK303288, BC021163
    UniProtKB/Swiss-Prot
    Q9ULV3
    UniProtKB/TrEMBL
    B4E0A3
    Related
    ENSP00000498625.1, ENST00000651955.1
    Conserved Domains (4) summary
    smart00451
    Location:531560
    ZnF_U1; U1-like zinc finger
    COG5112
    Location:605656
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]
    sd00020
    Location:595615
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:625649
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
  4. NM_001131018.2NP_001124490.1  cip1-interacting zinc finger protein isoform 4

    See identical proteins and their annotated locations for NP_001124490.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate exon in place of the first exon, lacks two alternate in-frame exons, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (4) is shorter at the N-terminus and lacks three alternate internal segments compared to isoform 5.
    Source sequence(s)
    BC021163, BM757318
    Consensus CDS
    CCDS48033.1
    UniProtKB/Swiss-Prot
    Q9ULV3
    Related
    ENSP00000362045.1, ENST00000372954.5
    Conserved Domains (4) summary
    smart00451
    Location:512541
    ZnF_U1; U1-like zinc finger
    COG5112
    Location:586637
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]
    sd00020
    Location:576596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:606630
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
  5. NM_001257975.2NP_001244904.1  cip1-interacting zinc finger protein isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript. The resulting isoform (5) may be the longest isoform; however, the N-terminus of this isoform is only predicted and not supported by experimental data.
    Source sequence(s)
    AK296363, AL590708, BC021163
    Consensus CDS
    CCDS75910.1
    UniProtKB/Swiss-Prot
    Q9ULV3
    UniProtKB/TrEMBL
    B7Z3U7, F5H2X7
    Related
    ENSP00000439244.2, ENST00000538431.5
    Conserved Domains (2) summary
    smart00451
    Location:622651
    ZnF_U1; U1-like zinc finger
    pfam12171
    Location:742766
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
  6. NM_001257976.2NP_001244905.1  cip1-interacting zinc finger protein isoform 6

    See identical proteins and their annotated locations for NP_001244905.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks another alternate exon compared to variant 6, that causes a frameshift. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5.
    Source sequence(s)
    AK303636, AL590708, BC021163
    Consensus CDS
    CCDS59147.1
    UniProtKB/Swiss-Prot
    Q9ULV3
    Related
    ENSP00000486816.1, ENST00000629610.2
    Conserved Domains (4) summary
    smart00451
    Location:491520
    ZnF_U1; U1-like zinc finger
    COG5112
    Location:565616
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]
    sd00020
    Location:555575
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:585609
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
  7. NM_012127.3NP_036259.2  cip1-interacting zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_036259.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate exon in place of the first exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5. Variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AF159025, AK023978, BC021163
    Consensus CDS
    CCDS6894.1
    UniProtKB/Swiss-Prot
    Q9ULV3, Q9Y3G0
    UniProtKB/TrEMBL
    A0A024R885
    Related
    ENSP00000489425.1, ENST00000634901.1
    Conserved Domains (4) summary
    smart00451
    Location:592621
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:656676
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:686710
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl26464
    Location:129482
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    128166065..128204222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    140373145..140411302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)