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GCSAM germinal center associated signaling and motility [ Homo sapiens (human) ]

Gene ID: 257144, updated on 21-Dec-2019

Summary

Official Symbol
GCSAMprovided by HGNC
Official Full Name
germinal center associated signaling and motilityprovided by HGNC
Primary source
HGNC:HGNC:20253
See related
Ensembl:ENSG00000174500 MIM:607792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGAL; GCAT2; GCET2
Summary
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 14.9), skin (RPKM 5.8) and 13 other tissues See more
Orthologs

Genomic context

See GCSAM in Genome Data Viewer
Location:
3q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (112120839..112133956, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (111839688..111852453, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 7 Neighboring gene chromosome 3 open reading frame 52 Neighboring gene microRNA 567 Neighboring gene TGF-beta induced lncRNA Neighboring gene solute carrier family 9 member C1 Neighboring gene chromosome 1 open reading frame 106 pseudogene Neighboring gene ubiquitination factor E4A (UFD2 homolog, yeast) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40441

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
myosin II binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of lymphocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
germinal center-associated signaling and motility protein
Names
germinal center B-cell-expressed transcript 2 protein
germinal center expressed transcript 2
germinal center-associated lymphoma protein
human germinal center-associated lymphoma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190259.2NP_001177188.1  germinal center-associated signaling and motility protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a longer protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC128688, AY212246, BM456595
    Consensus CDS
    CCDS54622.1
    UniProtKB/Swiss-Prot
    Q8N6F7
    Related
    ENSP00000419485.1, ENST00000484193.5
    Conserved Domains (1) summary
    pfam15666
    Location:73155
    HGAL; Germinal center-associated lymphoma
  2. NM_001190260.2NP_001177189.1  germinal center-associated signaling and motility protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC128688, AY212246, BP224611
    Consensus CDS
    CCDS54621.1
    UniProtKB/Swiss-Prot
    Q8N6F7
    Related
    ENSP00000420603.2, ENST00000460387.6
    Conserved Domains (1) summary
    pfam15666
    Location:56138
    HGAL; Germinal center-associated lymphoma
  3. NM_152785.5NP_689998.1  germinal center-associated signaling and motility protein isoform 1

    See identical proteins and their annotated locations for NP_689998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC128688, AF521911, AY212246
    Consensus CDS
    CCDS2964.1
    UniProtKB/Swiss-Prot
    Q8N6F7
    Related
    ENSP00000309487.4, ENST00000308910.9
    Conserved Domains (1) summary
    pfam15666
    Location:71153
    HGAL; Germinal center-associated lymphoma

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    112120839..112133956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453437.1XP_024309205.1  germinal center-associated signaling and motility protein isoform X2

    Conserved Domains (1) summary
    pfam15666
    Location:74154
    HGAL; Germinal center-associated lymphoma
  2. XM_011512627.3XP_011510929.1  germinal center-associated signaling and motility protein isoform X1

    Conserved Domains (1) summary
    pfam15666
    Location:76156
    HGAL; Germinal center-associated lymphoma
  3. XM_024453439.1XP_024309207.1  germinal center-associated signaling and motility protein isoform X5

    Conserved Domains (1) summary
    pfam15666
    Location:56136
    HGAL; Germinal center-associated lymphoma
  4. XM_024453438.1XP_024309206.1  germinal center-associated signaling and motility protein isoform X3

    Conserved Domains (1) summary
    pfam15666
    Location:69149
    HGAL; Germinal center-associated lymphoma
  5. XM_005247272.3XP_005247329.1  germinal center-associated signaling and motility protein isoform X5

    Conserved Domains (1) summary
    pfam15666
    Location:56136
    HGAL; Germinal center-associated lymphoma
  6. XM_011512629.2XP_011510931.1  germinal center-associated signaling and motility protein isoform X4

    See identical proteins and their annotated locations for XP_011510931.1

    Conserved Domains (1) summary
    pfam15666
    Location:57137
    HGAL; Germinal center-associated lymphoma
  7. XM_011512630.2XP_011510932.1  germinal center-associated signaling and motility protein isoform X4

    See identical proteins and their annotated locations for XP_011510932.1

    Conserved Domains (1) summary
    pfam15666
    Location:57137
    HGAL; Germinal center-associated lymphoma

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_019805492.1 Reference GRCh38.p13 PATCHES

    Range
    4129..16538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008756.1: Suppressed sequence

    Description
    NM_001008756.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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