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GCSAM germinal center associated signaling and motility [ Homo sapiens (human) ]

Gene ID: 257144, updated on 1-Mar-2024

Summary

Official Symbol
GCSAMprovided by HGNC
Official Full Name
germinal center associated signaling and motilityprovided by HGNC
Primary source
HGNC:HGNC:20253
See related
Ensembl:ENSG00000174500 MIM:607792; AllianceGenome:HGNC:20253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGAL; GCAT2; GCET2
Summary
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 14.9), skin (RPKM 5.8) and 13 other tissues See more
Orthologs
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Genomic context

See GCSAM in Genome Data Viewer
Location:
3q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (112120839..112133248, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (114841954..114854363, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (111839686..111852095, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:111804898-111805414 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:111820488-111821687 Neighboring gene chromosome 3 open reading frame 52 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20235 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:111845355-111845988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20237 Neighboring gene microRNA 567 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:111855415-111855934 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:111855935-111856453 Neighboring gene TGF-beta induced lncRNA Neighboring gene solute carrier family 9 member C1 Neighboring gene uncharacterized LOC124909407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:111904045-111904638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:111904639-111905231 Neighboring gene INAVA pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC40441

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables myosin II binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
germinal center-associated signaling and motility protein
Names
germinal center B-cell-expressed transcript 2 protein
germinal center expressed transcript 2
germinal center-associated lymphoma protein
human germinal center-associated lymphoma

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190259.2NP_001177188.1  germinal center-associated signaling and motility protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a longer protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC128688, AY212246, BM456595
    Consensus CDS
    CCDS54622.1
    UniProtKB/TrEMBL
    B2R8H0
    Related
    ENSP00000419485.1, ENST00000484193.5
    Conserved Domains (1) summary
    pfam15666
    Location:73155
    HGAL; Germinal center-associated lymphoma
  2. NM_001190260.2NP_001177189.1  germinal center-associated signaling and motility protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC128688, AY212246, BP224611
    Consensus CDS
    CCDS54621.1
    UniProtKB/TrEMBL
    B2R8H0
    Related
    ENSP00000420603.2, ENST00000460387.6
    Conserved Domains (1) summary
    pfam15666
    Location:56138
    HGAL; Germinal center-associated lymphoma
  3. NM_152785.5NP_689998.1  germinal center-associated signaling and motility protein isoform 1

    See identical proteins and their annotated locations for NP_689998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC128688, AF521911, AY212246
    Consensus CDS
    CCDS2964.1
    UniProtKB/Swiss-Prot
    C9JD17, C9JUG6, Q8N6F7
    UniProtKB/TrEMBL
    B2R8H0
    Related
    ENSP00000309487.4, ENST00000308910.9
    Conserved Domains (1) summary
    pfam15666
    Location:71153
    HGAL; Germinal center-associated lymphoma

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    112120839..112133248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453437.2XP_024309205.1  germinal center-associated signaling and motility protein isoform X2

    UniProtKB/TrEMBL
    B2R8H0
    Conserved Domains (1) summary
    pfam15666
    Location:74154
    HGAL; Germinal center-associated lymphoma
  2. XM_011512627.4XP_011510929.1  germinal center-associated signaling and motility protein isoform X1

    UniProtKB/TrEMBL
    B2R8H0
    Conserved Domains (1) summary
    pfam15666
    Location:76156
    HGAL; Germinal center-associated lymphoma
  3. XM_024453438.2XP_024309206.1  germinal center-associated signaling and motility protein isoform X3

    UniProtKB/TrEMBL
    B2R8H0
    Conserved Domains (1) summary
    pfam15666
    Location:69149
    HGAL; Germinal center-associated lymphoma
  4. XM_011512629.3XP_011510931.1  germinal center-associated signaling and motility protein isoform X4

    See identical proteins and their annotated locations for XP_011510931.1

    UniProtKB/TrEMBL
    B2R8H0
    Related
    ENSP00000418849.2, ENST00000487901.2
    Conserved Domains (1) summary
    pfam15666
    Location:57137
    HGAL; Germinal center-associated lymphoma
  5. XM_011512630.3XP_011510932.1  germinal center-associated signaling and motility protein isoform X4

    See identical proteins and their annotated locations for XP_011510932.1

    UniProtKB/TrEMBL
    B2R8H0
    Related
    ENSP00000419913.2, ENST00000488580.6
    Conserved Domains (1) summary
    pfam15666
    Location:57137
    HGAL; Germinal center-associated lymphoma

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_019805492.1 Reference GRCh38.p14 PATCHES

    Range
    4129..16538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332387.1XP_054188362.1  germinal center-associated signaling and motility protein isoform X2

    UniProtKB/TrEMBL
    B2R8H0
  2. XM_054332386.1XP_054188361.1  germinal center-associated signaling and motility protein isoform X1

    UniProtKB/TrEMBL
    B2R8H0
  3. XM_054332388.1XP_054188363.1  germinal center-associated signaling and motility protein isoform X3

    UniProtKB/TrEMBL
    B2R8H0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    114841954..114854363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346011.1XP_054201986.1  germinal center-associated signaling and motility protein isoform X2

    UniProtKB/TrEMBL
    B2R8H0
  2. XM_054346010.1XP_054201985.1  germinal center-associated signaling and motility protein isoform X1

    UniProtKB/TrEMBL
    B2R8H0
  3. XM_054346012.1XP_054201987.1  germinal center-associated signaling and motility protein isoform X3

    UniProtKB/TrEMBL
    B2R8H0

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008756.1: Suppressed sequence

    Description
    NM_001008756.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.