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Gcsam germinal center associated, signaling and motility [ Mus musculus (house mouse) ]

Gene ID: 14525, updated on 24-Apr-2022

Summary

Official Symbol
Gcsamprovided by MGI
Official Full Name
germinal center associated, signaling and motilityprovided by MGI
Primary source
MGI:MGI:102969
See related
Ensembl:ENSMUSG00000022659 AllianceGenome:MGI:102969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M17; Gcet; Gcet2; M17-L
Summary
Predicted to enable actin binding activity; myosin II binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of lymphocyte migration and regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human GCSAM (germinal center associated signaling and motility). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Gcsam in Genome Data Viewer
Location:
16; 16 B5
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45430803..45443230)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45610440..45622867)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (45610553..45622980)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 4 pseudogene Neighboring gene solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 Neighboring gene cDNA sequence, BC016579 Neighboring gene transmembrane serine protease 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables myosin II binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of lymphocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lymphocyte migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
germinal center-associated signaling and motility protein
Names
germinal center B-cell-expressed transcript 2 protein
germinal center expressed transcript 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159297.1NP_001152769.1  germinal center-associated signaling and motility protein isoform 1

    See identical proteins and their annotated locations for NP_001152769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK036553, AY500830, U13263
    Consensus CDS
    CCDS49861.1
    UniProtKB/Swiss-Prot
    Q6RFH4
    Related
    ENSMUSP00000123853.2, ENSMUST00000161347.9
    Conserved Domains (1) summary
    pfam15666
    Location:74155
    HGAL; Germinal center-associated lymphoma
  2. NM_008099.4NP_032125.3  germinal center-associated signaling and motility protein isoform 2

    See identical proteins and their annotated locations for NP_032125.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This difference results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK036553, U13263
    Consensus CDS
    CCDS28199.1
    UniProtKB/Swiss-Prot
    Q6RFH4
    Related
    ENSMUSP00000023339.5, ENSMUST00000023339.5
    Conserved Domains (1) summary
    pfam15666
    Location:52133
    HGAL; Germinal center-associated lymphoma

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45430803..45443230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)