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GLIPR1L1 GLIPR1 like 1 [ Homo sapiens (human) ]

Gene ID: 256710, updated on 15-Jun-2019

Summary

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Official Symbol
GLIPR1L1provided by HGNC
Official Full Name
GLIPR1 like 1provided by HGNC
Primary source
HGNC:HGNC:28392
See related
Ensembl:ENSG00000173401 MIM:610395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO7434; ALKN2972
Expression
Biased expression in testis (RPKM 4.4) and fat (RPKM 0.2) See more
Orthologs
all

Genomic context

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See GLIPR1L1 in Genome Data Viewer
Location:
12q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (75331834..75370390)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75727550..75764170)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107983975 Neighboring gene cyclin G2 pseudogene 1 Neighboring gene calcyphosine 2 Neighboring gene necdin, MAGE family member pseudogene Neighboring gene GLIPR1 like 2 Neighboring gene GLI pathogenesis related 1 Neighboring gene KRR1 small subunit processome component homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding. Gibbs GM, et al. Endocrinology, 2010 May. PMID 20219979
  2. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Ren C, et al. Genomics, 2006 Aug. PMID 16714093
  3. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Kim DY, et al. Mol Cell, 2013 Feb 21. PMID 23333304, Free PMC Article
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013

See all (9) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of GLI pathogenesis-related 1 like 1 (GLIPR1L1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

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Homology

Clone Names

  • MGC26856

Gene Ontology Provided by GOA

Process Evidence Code Pubs
single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
  
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
  
plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GLIPR1-like protein 1
Names
GLI pathogenesis related 1 like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304964.2 → NP_001291893.1  GLIPR1-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001291893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC121761, AY358731, BC014603, BG196035
    Consensus CDS
    CCDS76578.1
    UniProtKB/Swiss-Prot
    Q6UWM5
    Related
    ENSP00000367967.4, ENST00000378695.8
    Conserved Domains (1) summary
    cd05385
    Location:32 → 174
    SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

  2. NM_152779.4 → NP_689992.1  GLIPR1-like protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_689992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC121761, AY358731, BC014603, BG196035
    Consensus CDS
    CCDS9009.1
    UniProtKB/Swiss-Prot
    Q6UWM5
    Related
    ENSP00000310770.2, ENST00000312442.2
    Conserved Domains (1) summary
    cd05385
    Location:32 → 174
    SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    75331834..75370560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019134.1 → XP_016874623.1  GLIPR1-like protein 1 isoform X2

  2. XM_011538134.3 → XP_011536436.2  GLIPR1-like protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UWM5.2 GenPept UniProtKB/Swiss-Prot:Q6UWM5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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