GLIPR1L1 GLIPR1 like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GLIPR1L1provided by HGNC
Official Full Name: GLIPR1 like 1provided by HGNC
Primary source: HGNC:HGNC:28392
See related: Ensembl:ENSG00000173401 MIM:610395; AllianceGenome:HGNC:28392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRO7434; ALKN2972
Summary: Predicted to be involved in single fertilization. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in sperm connecting piece. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis (RPKM 4.4) and fat (RPKM 0.2) See more
Orthologs: all
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Genomic context

Location:: 12q21.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (75334670..75370560)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (75309262..75345149)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (75728450..75764340)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif downregulates the expression of GLI pathogenesis-related 1 like 1 (GLIPR1L1) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

General gene information

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Homology

Homologs of the GLIPR1L1 gene: The GLIPR1L1 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, and frog.
Orthologs from Annotation Pipeline: 151 organisms have orthologs with human gene GLIPR1L1
Orthologs

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: GLIPR1-like protein 1

Names: GLI pathogenesis related 1 like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304964.2 → NP_001291893.1 GLIPR1-like protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001291893.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC121761, AY358731, BC014603, BG196035

Consensus CDS

CCDS76578.1

UniProtKB/Swiss-Prot

Q6UWM5, Q96L06

Related

ENSP00000367967.4, ENST00000378695.9

Conserved Domains (1) summary

cd05385
Location:32 → 174

SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...
NM_152779.4 → NP_689992.1 GLIPR1-like protein 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_689992.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AC121761, AY358731, BC014603, BG196035

Consensus CDS

CCDS9009.1

UniProtKB/Swiss-Prot

Q6UWM5

Related

ENSP00000310770.2, ENST00000312442.2

Conserved Domains (1) summary

cd05385
Location:32 → 174

SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...