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ST6GALNAC3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 256435, updated on 1-Jun-2020

Summary

Official Symbol
ST6GALNAC3provided by HGNC
Official Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:19343
See related
Ensembl:ENSG00000184005 MIM:610133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STY; SIAT7C; PRO7177; ST6GALNACIII
Summary
ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in thyroid (RPKM 2.3), kidney (RPKM 1.6) and 19 other tissues See more
Orthologs

Genomic context

See ST6GALNAC3 in Genome Data Viewer
Location:
1p31.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (76074734..76637316)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (76540389..77100311)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378806 Neighboring gene uncharacterized LOC101927342 Neighboring gene peroxiredoxin 5 pseudogene Neighboring gene uncharacterized LOC105378807 Neighboring gene triosephosphate isomerase 1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 161, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
NHGRI GWA Catalog
Genome-wide association study of circulating vitamin D-binding protein.
NHGRI GWA Catalog
Genome-wide association study of liver enzymes in korean children.
NHGRI GWA Catalog
Germline genomic variants associated with childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13669, FLJ27239

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ganglioside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycoprotein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycosphingolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycosylceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
sialylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Names
GalNAc alpha-2,6-sialyltransferase III
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltran
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
ST6 GalNAc alpha-2,6-sialyltransferase 3
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase III
sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C
sialyltransferase 7C
NP_001153483.1
NP_001336034.1
NP_001336035.1
NP_001336036.1
NP_001336037.1
NP_001336038.1
NP_001336039.1
NP_001336040.1
NP_694541.2
XP_016856426.1
XP_016856427.1
XP_016856428.1
XP_016856430.1
XP_016856431.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160011.3NP_001153483.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 2

    See identical proteins and their annotated locations for NP_001153483.1

    Status: VALIDATED

    Source sequence(s)
    AY358540, BC039520
    UniProtKB/Swiss-Prot
    Q8NDV1
    Conserved Domains (1) summary
    pfam00777
    Location:77137
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001349105.2NP_001336034.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104458, AK297363
    Conserved Domains (1) summary
    pfam00777
    Location:5194
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001349106.2NP_001336035.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092813, AC103592, AC104458
    Conserved Domains (1) summary
    pfam00777
    Location:3207
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. NM_001349107.2NP_001336036.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC092813, AC103592, AC104458
    Conserved Domains (1) summary
    pfam00777
    Location:70259
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. NM_001349108.2NP_001336037.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC092813, AC103592, AC104458
    Conserved Domains (1) summary
    pfam00777
    Location:5230
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. NM_001349109.2NP_001336038.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC092813, AC103592, AC104458
    Conserved Domains (1) summary
    pfam00777
    Location:70142
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. NM_001349110.2NP_001336039.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC092813, AC098655, AC103592
    Conserved Domains (1) summary
    pfam00777
    Location:70142
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. NM_001349111.2NP_001336040.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC092813, AC103592, AC104458
    Conserved Domains (1) summary
    pfam00777
    Location:82307
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. NM_152996.4NP_694541.2  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 1

    See identical proteins and their annotated locations for NP_694541.2

    Status: VALIDATED

    Source sequence(s)
    AC104458, BC059363, DA800675
    Consensus CDS
    CCDS672.1
    UniProtKB/Swiss-Prot
    Q8NDV1
    Related
    ENSP00000329214.3, ENST00000328299.4
    Conserved Domains (1) summary
    pfam00777
    Location:77295
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_146056.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092813, AC098655, AC103592, AC104458

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    76074734..76637316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000942.2XP_016856431.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:3207
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_017000938.1XP_016856427.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X2

  3. XM_017000939.1XP_016856428.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X3

  4. XM_017000937.2XP_016856426.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X1

  5. XM_017000941.2XP_016856430.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:3207
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_001737094.2 RNA Sequence

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