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St6galnac3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 20447, updated on 8-Nov-2022

Summary

Official Symbol
St6galnac3provided by MGI
Official Full Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3provided by MGI
Primary source
MGI:MGI:1341828
See related
Ensembl:ENSMUSG00000052544 AllianceGenome:MGI:1341828
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat7c
Summary
Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in ceramide metabolic process; oligosaccharide metabolic process; and protein glycosylation. Predicted to be located in nucleoplasm. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; lung; mammary gland; and nervous system. Orthologous to human ST6GALNAC3 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 1.3), placenta adult (RPKM 1.2) and 24 other tissues See more
Orthologs
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Genomic context

See St6galnac3 in Genome Data Viewer
Location:
3; 3 H3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152903911..153430846, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (153198274..153725133, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930482G09 gene Neighboring gene RIKEN cDNA 1700094M23 gene Neighboring gene predicted gene, 54205 Neighboring gene predicted gene, 33066 Neighboring gene predicted gene, 54206 Neighboring gene RIKEN cDNA 1700012D16 gene Neighboring gene predicted gene, 52634 Neighboring gene predicted gene, 32721 Neighboring gene predicted gene, 52633 Neighboring gene ubiquitin-conjugating enzyme E2 L3 pseudogene Neighboring gene predicted gene, 22206 Neighboring gene RIKEN cDNA 5730460C07 gene Neighboring gene predicted gene, 25757

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycosphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycosylceramide metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Names
SIAT7-C
ST6GalNAc III
ST6GalNAcIII
STY
galNAc alpha-2,6-sialyltransferase III
sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C
sialyltransferase 7C
NP_035502.1
XP_006501282.1
XP_006501283.1
XP_006501284.1
XP_006501285.1
XP_011238356.1
XP_030108369.1
XP_030108370.1
XP_030108371.1
XP_030108372.1
XP_036018881.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011372.2NP_035502.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

    See identical proteins and their annotated locations for NP_035502.1

    Status: PROVISIONAL

    Source sequence(s)
    AC103637, AC121914, AC133943, AC163209
    Consensus CDS
    CCDS38677.1
    UniProtKB/Swiss-Prot
    Q9JHP5, Q9WUV2
    UniProtKB/TrEMBL
    A0A8C6GMI2, Q544M3
    Related
    ENSMUSP00000143747.2, ENSMUST00000200397.5
    Conserved Domains (1) summary
    pfam00777
    Location:77297
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    152903911..153430846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252510.1XP_030108370.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X4

    UniProtKB/TrEMBL
    A0A6P7QQD4
    Conserved Domains (1) summary
    pfam00777
    Location:53273
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_006501220.5XP_006501283.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:72292
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_006501221.5XP_006501284.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:87149
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_006501219.5XP_006501282.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:87307
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_030252512.1XP_030108372.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X8

    UniProtKB/TrEMBL
    A0A6P7R352
    Conserved Domains (1) summary
    pfam00777
    Location:7209
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. XM_030252511.2XP_030108371.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X6

    Conserved Domains (1) summary
    pfam00777
    Location:12232
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. XM_036162988.1XP_036018881.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X8

    UniProtKB/TrEMBL
    A0A6P7R352
    Conserved Domains (1) summary
    pfam00777
    Location:7209
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. XM_030252509.1XP_030108369.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X4

    UniProtKB/TrEMBL
    A0A6P7QQD4
    Conserved Domains (1) summary
    pfam00777
    Location:53273
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. XM_011240054.4XP_011238356.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X7

    Conserved Domains (1) summary
    pfam00777
    Location:87149
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  10. XM_006501222.5XP_006501285.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:87149
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_004941299.1 RNA Sequence

  2. XR_003954302.2 RNA Sequence