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EPGN epithelial mitogen [ Homo sapiens (human) ]

Gene ID: 255324, updated on 23-May-2018
Official Symbol
EPGNprovided by HGNC
Official Full Name
epithelial mitogenprovided by HGNC
Primary source
HGNC:HGNC:17470
See related
Ensembl:ENSG00000182585 Vega:OTTHUMG00000160869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPG; PRO9904; ALGV3072
Summary
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Restricted expression toward esophagus (RPKM 11.2) See more
Orthologs
See EPGN in Genome Data Viewer
Location:
4q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (74307585..74316803)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (75174187..75182520)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377277 Neighboring gene C-X-C motif chemokine ligand 2 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like Neighboring gene uncharacterized LOC105377276 Neighboring gene epiregulin Neighboring gene amphiregulin

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
NHGRI GWA Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog

Markers

Homology

Clone Names

  • FLJ75542

Gene Ontology Provided by GOA

Function Evidence Code Pubs
epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epidermal growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
epigen
Names
epithelial mitogen homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270989.1NP_001257918.1  epigen isoform 1 precursor

    See identical proteins and their annotated locations for NP_001257918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC097470, AK289455, CB150835
    Consensus CDS
    CCDS59478.1
    UniProtKB/Swiss-Prot
    Q6UW88
    Related
    ENSP00000411898.1, OTTHUMP00000219187, ENST00000413830.5, OTTHUMT00000362738
    Conserved Domains (1) summary
    cl28647
    Location:60100
    PHA02887; EGF-like protein; Provisional
  2. NM_001270990.1NP_001257919.1  epigen isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257919.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 2 (also known as isoform B) which is shorter than isoform 1.
    Source sequence(s)
    AC097470, CB150835, DQ235264
    Consensus CDS
    CCDS59477.1
    UniProtKB/Swiss-Prot
    Q6UW88
    Related
    ENSP00000425890.1, OTTHUMP00000219191, ENST00000503098.5, OTTHUMT00000362742
    Conserved Domains (1) summary
    cl28647
    Location:6095
    PHA02887; EGF-like protein; Provisional
  3. NM_001270991.1NP_001257920.1  epigen isoform 3 precursor

    See identical proteins and their annotated locations for NP_001257920.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses alternate in-frame splice sites in two exons in the coding region compared to variant 1. It encodes isoform 3 (also known as isoform F) which is shorter than isoform 1.
    Source sequence(s)
    AC097470, CB150835, DQ235264, DQ235268
    Consensus CDS
    CCDS59475.1
    UniProtKB/Swiss-Prot
    Q6UW88
    Related
    ENSP00000426550.1, OTTHUMP00000219190, ENST00000514968.5, OTTHUMT00000362741
    Conserved Domains (1) summary
    cl28647
    Location:5186
    PHA02887; EGF-like protein; Provisional
  4. NM_001270992.1NP_001257921.1  epigen isoform 4 precursor

    See identical proteins and their annotated locations for NP_001257921.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 4 (also known as isoform E) which is shorter than isoform 1.
    Source sequence(s)
    AC097470, CB150835, DQ235267
    Consensus CDS
    CCDS59479.1
    UniProtKB/Swiss-Prot
    Q6UW88
    Related
    ENSP00000426678.1, OTTHUMP00000219192, ENST00000502358.5, OTTHUMT00000362743
  5. NM_001270993.1NP_001257922.1  epigen isoform 5 precursor

    See identical proteins and their annotated locations for NP_001257922.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 5 (also known as isoform G) which is shorter than isoform 1.
    Source sequence(s)
    AC097470, CB150835, DQ235265
    Consensus CDS
    CCDS59476.1
    UniProtKB/Swiss-Prot
    Q6UW88
    Related
    ENSP00000424392.1, OTTHUMP00000219194, ENST00000505212.5, OTTHUMT00000362745

RNA

  1. NR_073114.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site and an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097470, BC127938, CB150835
  2. NR_073117.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two alternate internal exons compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AC097470, CB150835, DQ235266

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    74307585..74316803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531817.3XP_011530119.1  epigen isoform X1

    See identical proteins and their annotated locations for XP_011530119.1

    Related
    ENSP00000398415.2, OTTHUMP00000219195, ENST00000446430.2
    Conserved Domains (2) summary
    PHA02887
    Location:5191
    PHA02887; EGF-like protein; Provisional
    PHA03099
    Location:1194
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013442.1: Suppressed sequence

    Description
    NM_001013442.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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