Lgals4 galectin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lgals4provided by RGD
Official Full Name: galectin 4provided by RGD
Primary source: RGD:3003
See related: Ensembl:ENSRNOG00000020338 AllianceGenome:RGD:3003
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: L-36; L36LBI
Summary: Predicted to enable galactoside binding activity. Predicted to be located in extracellular space. Orthologous to human LGALS4 (galectin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 31.5), Liver (RPKM 5.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (93248463..93260002)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (84124766..84132481)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (87019598..87027720)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest a possible mechanism by which autophagy regulates trophoblast differentiation via regulation of galectin-4 (Gal-4) expression in order to establish the maternal-fetal interface.
Title: Galectin-4 expression is down-regulated in response to autophagy during differentiation of rat trophoblast cells.
Gal-4 sorts to axon plasma membrane segments by binding to sulfatide-containing microtubule-associated carriers and organizes the transport of L1, and likely other axonal glycoproteins, by attaching them to the carriers through their LacNAc termini.
Title: Neuronal Galectin-4 is required for axon growth and for the organization of axonal membrane L1 delivery and clustering.
In the rat placenta, immunohistochemical analysis showed that Gal4 is preferentially located in the maternal-fetal junctional zone. These results suggest that down-regulation of Gal4 may be involved in the promotion of trophoblast cell differentiation
Title: Expression pattern of Galectin 4 in rat placentation.
This study demonistrated that neuronal galectin-4 as a candidate for a soluble regulator of OLG differentiation and, hence, myelination.
Title: Galectin-4, a novel neuronal regulator of myelination.
The expression of galectin 4 was determined in the rat small intestine during postnatal development.
Title: Expression of galectin 4 in the rat small intestine during postnatal development.

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General gene information

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Markers

RH139632 (e-PCR)
- UniSTS:221716

RH140494 (e-PCR)
- UniSTS:221716

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables galactoside binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antibacterial peptide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: galectin-4

Names: L-36 lactose-binding protein; L36LBP; Lectin, galactose binding, soluble 4 (Galectin-4); gal-4; lactose-binding lectin 4; lectin, galactoside-binding, soluble, 4 (galectin 4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.