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LGALS4 galectin 4 [ Homo sapiens (human) ]

Gene ID: 3960, updated on 7-Dec-2018

Summary

Official Symbol
LGALS4provided by HGNC
Official Full Name
galectin 4provided by HGNC
Primary source
HGNC:HGNC:6565
See related
Ensembl:ENSG00000171747 MIM:602518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL4; L36LBP
Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 740.5), duodenum (RPKM 465.8) and 4 other tissues See more
Orthologs

Genomic context

See LGALS4 in Genome Data Viewer
Location:
19q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (38801671..38813614, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39292311..39303740, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene galectin 7B Neighboring gene RNA, U6 small nuclear 140, pseudogene Neighboring gene enoyl-CoA hydratase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein L

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
galactoside binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
galectin-4
Names
L-36 lactose-binding protein
antigen NY-CO-27
gal-4
lactose-binding lectin 4
lectin, galactoside-binding, soluble, 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006149.4NP_006140.1  galectin-4

    See identical proteins and their annotated locations for NP_006140.1

    Status: REVIEWED

    Source sequence(s)
    AA130458, AK290269
    Consensus CDS
    CCDS12521.1
    UniProtKB/Swiss-Prot
    P56470
    UniProtKB/TrEMBL
    Q6FHZ4
    Related
    ENSP00000302100.3, ENST00000307751.8
    Conserved Domains (2) summary
    smart00908
    Location:199322
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:18147
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    38801671..38813614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526974.2XP_011525276.1  galectin-4 isoform X2

    See identical proteins and their annotated locations for XP_011525276.1

    Conserved Domains (1) summary
    smart00908
    Location:68191
    Gal-bind_lectin; Galactoside-binding lectin
  2. XM_011526973.2XP_011525275.1  galectin-4 isoform X1

    Conserved Domains (2) summary
    smart00908
    Location:186309
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:18147
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p12 PATCHES

    Range
    211354..222772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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