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IFI6 interferon alpha inducible protein 6 [ Homo sapiens (human) ]

Gene ID: 2537, updated on 1-Jun-2020

Summary

Official Symbol
IFI6provided by HGNC
Official Full Name
interferon alpha inducible protein 6provided by HGNC
Primary source
HGNC:HGNC:4054
See related
Ensembl:ENSG00000126709 MIM:147572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
6-16; G1P3; FAM14C; IFI616; IFI-6-16
Summary
This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 111.6), salivary gland (RPKM 40.6) and 21 other tissues See more
Orthologs

Genomic context

See IFI6 in Genome Data Viewer
Location:
1p35.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (27666061..27672229, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27992572..27998724, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC729973 Neighboring gene long intergenic non-protein coding RNA 2574 Neighboring gene RNA, U6 small nuclear 949, pseudogene Neighboring gene charged multivesicular body protein 1A pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 LAI infection downregulates UBD (FAT10) and IFI6 mRNA levels in HeLa cells, which results from IFNG signaling inhibition PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of interferon alpha-inducible protein 6 (IFI6) in human B cells PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of IFI6 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial depolarization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interferon alpha-inducible protein 6
Names
interferon, alpha-inducible protein clone IFI-6-16
interferon-induced protein 6-16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002038.4NP_002029.3  interferon alpha-inducible protein 6 isoform a precursor

    See identical proteins and their annotated locations for NP_002029.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (a).
    Source sequence(s)
    AK024814, AL445490
    Consensus CDS
    CCDS306.1
    UniProtKB/Swiss-Prot
    P09912
    Related
    ENSP00000354736.6, ENST00000361157.11
    Conserved Domains (1) summary
    pfam06140
    Location:46117
    Ifi-6-16; Interferon-induced 6-16 family
  2. NM_022872.3NP_075010.1  interferon alpha-inducible protein 6 isoform b precursor

    See identical proteins and their annotated locations for NP_075010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alterative, in-frame splice site compared to variant 1. The encoded isoform (b) is longer than isoform a.
    Source sequence(s)
    AK024814, AL445490
    Consensus CDS
    CCDS307.1
    UniProtKB/Swiss-Prot
    P09912
    Related
    ENSP00000355152.4, ENST00000362020.4
    Conserved Domains (1) summary
    pfam06140
    Location:50111
    Ifi-6-16; Interferon-induced 6-16 family
  3. NM_022873.3NP_075011.1  interferon alpha-inducible protein 6 isoform c precursor

    See identical proteins and their annotated locations for NP_075011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alterative, in-frame splice site compared to variant 1. The encoded isoform (c) is longer than isoform a.
    Source sequence(s)
    AK024814, AL445490
    Consensus CDS
    CCDS308.1
    UniProtKB/Swiss-Prot
    P09912
    Related
    ENSP00000342513.4, ENST00000339145.8
    Conserved Domains (1) summary
    pfam06140
    Location:54115
    Ifi-6-16; Interferon-induced 6-16 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    27666061..27672229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446207.1XP_024301975.1  interferon alpha-inducible protein 6 isoform X1

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