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FYB1 FYN binding protein 1 [ Homo sapiens (human) ]

Gene ID: 2533, updated on 3-Jan-2019

Summary

Official Symbol
FYB1provided by HGNC
Official Full Name
FYN binding protein 1provided by HGNC
Primary source
HGNC:HGNC:4036
See related
Ensembl:ENSG00000082074 MIM:602731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FYB; ADAP; THC3; PRO0823; SLAP130; SLAP-130
Summary
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Expression
Broad expression in appendix (RPKM 36.5), lymph node (RPKM 32.7) and 15 other tissues See more
Orthologs

Genomic context

See FYB1 in Genome Data Viewer
Location:
5p13.1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (39105252..39274500, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (39105354..39270759, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene oncostatin M receptor Neighboring gene RPTOR independent companion of MTOR complex 2 Neighboring gene androgen induced 1 pseudogene 1 Neighboring gene golgin A5 pseudogene 1 Neighboring gene complement C9 Neighboring gene DAB2, clathrin adaptor protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
    Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
    Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...
  • T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
  • TCR signaling, organism-specific biosystem (from REACTOME)
    TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
  • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD4+ T cells, organism-specific biosystem
    TCR signaling in naive CD4+ T cells

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
biological_process ND
No biological Data available
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
FYN-binding protein 1
Names
FYB-120/130
FYN-T-binding protein
FYN-binding protein
SLP-76-associated phosphoprotein
adhesion and degranulation-promoting adaptor protein
p120/p130

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029596.2 RefSeqGene

    Range
    5001..170406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243093.1NP_001230022.1  FYN-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001230022.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC008964, AK290403, AK297077, BQ015514
    Consensus CDS
    CCDS58945.1
    UniProtKB/Swiss-Prot
    O15117
    Related
    ENSP00000425845.2, ENST00000512982.3
    Conserved Domains (2) summary
    pfam14603
    Location:757839
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:518612
    SH3; Src Homology 3 domain superfamily
  2. NM_001349333.1NP_001336262.1  FYN-binding protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream start codon compared to variant 3. The resulting isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC008964, AC025471, AK297077, BC117449, BQ015514, DA452064, DA585094
    Consensus CDS
    CCDS54848.1
    Conserved Domains (3) summary
    pfam14603
    Location:742829
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:508602
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:40427
    Atrophin-1; Atrophin-1 family
  3. NM_001465.5NP_001456.3  FYN-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001456.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses a downstream start codon compared to variant 3. The resulting isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC008964, AK297077, AV761195, BC117449, BQ015514, DA585094
    Consensus CDS
    CCDS54848.1
    UniProtKB/Swiss-Prot
    O15117
    Related
    ENSP00000427114.1, ENST00000505428.5
    Conserved Domains (3) summary
    pfam14603
    Location:742829
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:508602
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:40427
    Atrophin-1; Atrophin-1 family
  4. NM_018594.2NP_061064.2  FYN-binding protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AC008964, AC010633, AC025471
    Conserved Domains (3) summary
    pfam14603
    Location:706793
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:518612
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:50437
    Atrophin-1; Atrophin-1 family
  5. NM_199335.4NP_955367.1  FYN-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_955367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The resulting isoform (2) has a shorter N-terminus and lacks an internal segment compared to isoform 3.
    Source sequence(s)
    AC008964, AF001862, AK297077, AV761195, BC015933, BQ015514, DA585094
    Consensus CDS
    CCDS47200.1
    UniProtKB/Swiss-Prot
    O15117
    Related
    ENSP00000316460.7, ENST00000351578.11
    Conserved Domains (2) summary
    pfam14603
    Location:701783
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:508602
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    39105252..39274500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714464.3XP_006714527.1  FYN-binding protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006714527.1

    UniProtKB/Swiss-Prot
    O15117
    Conserved Domains (3) summary
    pfam14603
    Location:742829
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:508602
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:40427
    Atrophin-1; Atrophin-1 family
  2. XM_011514011.2XP_011512313.1  FYN-binding protein 1 isoform X3

    Conserved Domains (3) summary
    pfam14603
    Location:706793
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:518612
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:50437
    Atrophin-1; Atrophin-1 family
  3. XM_011514010.1XP_011512312.1  FYN-binding protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011512312.1

    UniProtKB/Swiss-Prot
    O15117
    Conserved Domains (3) summary
    pfam14603
    Location:742829
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:508602
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:40427
    Atrophin-1; Atrophin-1 family
  4. XM_011514008.3XP_011512310.1  FYN-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011512310.1

    UniProtKB/Swiss-Prot
    O15117
    Conserved Domains (2) summary
    pfam14603
    Location:757839
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:518612
    SH3; Src Homology 3 domain superfamily
  5. XM_011514009.1XP_011512311.1  FYN-binding protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011512311.1

    UniProtKB/Swiss-Prot
    O15117
    Conserved Domains (3) summary
    pfam14603
    Location:742829
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:508602
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:40427
    Atrophin-1; Atrophin-1 family
  6. XM_006714466.2XP_006714529.1  FYN-binding protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006714529.1

    UniProtKB/Swiss-Prot
    O15117
    Conserved Domains (3) summary
    pfam14603
    Location:742829
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:508602
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:40427
    Atrophin-1; Atrophin-1 family
  7. XM_017009316.1XP_016864805.1  FYN-binding protein 1 isoform X4

    Conserved Domains (3) summary
    pfam14603
    Location:706793
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:518612
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:50437
    Atrophin-1; Atrophin-1 family
  8. XM_011514012.3XP_011512314.1  FYN-binding protein 1 isoform X5

    Conserved Domains (1) summary
    cl17036
    Location:518612
    SH3; Src Homology 3 domain superfamily
  9. XM_011514013.3XP_011512315.1  FYN-binding protein 1 isoform X6

    Conserved Domains (1) summary
    PHA03247
    Location:50437
    PHA03247; large tegument protein UL36; Provisional
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