U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fyb FYN binding protein [ Mus musculus (house mouse) ]

Gene ID: 23880, updated on 26-Sep-2022

Summary

Official Symbol
Fybprovided by MGI
Official Full Name
FYN binding proteinprovided by MGI
Primary source
MGI:MGI:1346327
See related
Ensembl:ENSMUSG00000022148 AllianceGenome:MGI:1346327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADAP; Fyb1; Slap130; p120/130; p120/p130; FYB-120/130; B630013F22Rik
Summary
The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Expression
Biased expression in thymus adult (RPKM 13.6), spleen adult (RPKM 5.7) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fyb in Genome Data Viewer
Location:
15; 15 A1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (6552280..6695089)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (6522796..6665608)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene disabled 2, mitogen-responsive phosphoprotein Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene complement component 9 Neighboring gene predicted gene 2245 Neighboring gene prohibitin pseudogene Neighboring gene RPTOR independent companion of MTOR, complex 2 Neighboring gene predicted gene, 53882 Neighboring gene oncostatin M receptor Neighboring gene predicted gene, 41261

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT acts_upstream_of_or_within mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
FYN-binding protein 1
Names
FYN binding protein FYB-130
FYN-T-binding protein
SLP-76-associated phosphoprotein
adhesion and degranulation promoting adaptor protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278269.1NP_001265198.1  FYN-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001265198.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC158901, AC161196, AK137907
    UniProtKB/Swiss-Prot
    O35601
    Conserved Domains (2) summary
    pfam14603
    Location:691773
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:496591
    SH3; Src Homology 3 domain superfamily
  2. NM_011815.5NP_035945.1  FYN-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_035945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158901, AC161196
    Consensus CDS
    CCDS37031.1
    UniProtKB/Swiss-Prot
    O35601, Q9Z2H3
    UniProtKB/TrEMBL
    B2RUR0
    Related
    ENSMUSP00000087947.6, ENSMUST00000090461.12
    Conserved Domains (2) summary
    pfam14603
    Location:737819
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:496591
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    6552280..6695089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245328.3XP_011243630.1  FYN-binding protein 1 isoform X1

    Conserved Domains (2) summary
    pfam07653
    Location:513568
    SH3_2; Variant SH3 domain
    pfam14603
    Location:750837
    hSH3; Helically-extended SH3 domain
  2. XM_011245329.3XP_011243631.1  FYN-binding protein 1 isoform X4

    Conserved Domains (2) summary
    pfam07653
    Location:513568
    SH3_2; Variant SH3 domain
    pfam14603
    Location:704791
    hSH3; Helically-extended SH3 domain
  3. XM_006519982.2XP_006520045.1  FYN-binding protein 1 isoform X2

    Conserved Domains (2) summary
    pfam07653
    Location:513568
    SH3_2; Variant SH3 domain
    pfam14603
    Location:742829
    hSH3; Helically-extended SH3 domain
  4. XM_006519985.2XP_006520048.1  FYN-binding protein 1 isoform X5

    Conserved Domains (2) summary
    pfam07653
    Location:513568
    SH3_2; Variant SH3 domain
    pfam14603
    Location:696783
    hSH3; Helically-extended SH3 domain
  5. XM_036159389.1XP_036015282.1  FYN-binding protein 1 isoform X6

    Conserved Domains (1) summary
    cl17036
    Location:506601
    SH3; Src Homology 3 domain superfamily
  6. XM_006519983.4XP_006520046.1  FYN-binding protein 1 isoform X3

    Conserved Domains (2) summary
    pfam07653
    Location:503558
    SH3_2; Variant SH3 domain
    pfam14603
    Location:740827
    hSH3; Helically-extended SH3 domain
  7. XM_006519986.1XP_006520049.1  FYN-binding protein 1 isoform X7

    Conserved Domains (2) summary
    pfam07653
    Location:73128
    SH3_2; Variant SH3 domain
    pfam14603
    Location:310397
    hSH3; Helically-extended SH3 domain