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Pcdhga4 protocadherin gamma subfamily A, 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252894, updated on 17-Aug-2024

Summary

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Official Symbol
Pcdhga4provided by RGD
Official Full Name
protocadherin gamma subfamily A, 4provided by RGD
Primary source
RGD:620725
See related
AllianceGenome:RGD:620725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pcdhga3
Summary
Predicted to enable calcium ion binding activity. Involved in spermatogenesis. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
18p11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (29760777..29794877)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (29508152..29543103)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (30831036..30834819)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 605 like 1 Neighboring gene protocadherin gamma subfamily A, 1 Neighboring gene protocadherin gamma subfamily A, 2 Neighboring gene protocadherin gamma subfamily A, 3 Neighboring gene protocadherin gamma subfamily B, 1 Neighboring gene uncharacterized LOC103694196 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene protocadherin gamma subfamily A, 5 Neighboring gene protocadherin gamma subfamily A, 7 Neighboring gene protocadherin gamma subfamily A, 8 Neighboring gene protocadherin gamma subfamily A, 9 Neighboring gene protocadherin gamma subfamily A, 10 Neighboring gene protocadherin gamma subfamily B, 7 Neighboring gene protocadherin gamma subfamily A, 11 Neighboring gene protocadherin gamma subfamily B, 8 Neighboring gene protocadherin gamma subfamily A, 12 Neighboring gene protocadherin gamma subfamily C, 3 Neighboring gene protocadherin gamma subfamily C, 5 Neighboring gene diaphanous-related formin 1 Neighboring gene uncharacterized LOC120098325

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, et al. Endocrinology, 2000 Feb. PMID 10650949
  2. Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha. Murata Y, et al. J Biol Chem, 2004 Nov 19. PMID 15347688
  3. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article
  4. Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Wu Q. Genetics, 2005 Apr. PMID 15744052, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protocadherin gamma-A4; protocadherin gamma-A6
Names
protocadherin gamma subfamily A, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432426.1 → NP_001419355.1  protocadherin gamma-A4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    29760777..29794877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772071.4 → XP_008770293.3  protocadherin gamma-A4 isoform X1

    UniProtKB/TrEMBL
    A6J388
    Conserved Domains (3) summary
    cd11304
    Location:245 → 342
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:29 → 111
    Cadherin_2; Cadherin-like
    pfam16492
    Location:687 → 771
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

  2. XM_039097401.2 → XP_038953329.1  protocadherin gamma-A6 isoform X2

    UniProtKB/TrEMBL
    A6J395
    Conserved Domains (3) summary
    cd11304
    Location:243 → 340
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:27 → 109
    Cadherin_2; Cadherin-like
    pfam16492
    Location:685 → 769
    Cadherin_C_2; Cadherin cytoplasmic C-terminal
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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