Conserved Protein Domain Family
Cadherin_C_2

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pfam16492: Cadherin_C_2 (this model, PSSM-Id:406805 is obsolete and has been replaced by 465139)
Cadherin cytoplasmic C-terminal
Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.
Statistics
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PSSM-Id: 406805
Aligned: 134 rows
Threshold Bit Score: 41.3341
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002804241   713 DLTLILIIALGSVSFIFLLAMIVL-AVRCQKEKKLNIYTClasdcclcccccggggstccgrqararkkklsksdimlVQ 791  Rhesus monkey
XP_003404856   686 PSTKYLVISLAVLSFVFLFSVTVIfIIHIYQKIKYKEKFTvqeh------------------------------------ 729  African sava...
XP_005209567   686 PSTKYLVISLAVLSFLFLLSVTVIfIIHICQKIKHREKFTiqeh------------------------------------ 729  cattle
ELW54080       686 PSTKYLVISLAVLSFLFLLSVTLIsIIHIYQKIKNREKFTiqeh------------------------------------ 729  Chinese tree...
XP_016160885   690 MLTTYLIASLCCVSSLFVLSVLVLtANTFCKTRVRADLPP--------------------------------------AS 731  Collared fly...
20_pfamImport    1 RLTLYLIICLSCVSALFLATAAAAvVVRLRRARQSMAGPL---------------------------------------- 40  
XP_016848527   683 TLTMYLVICLASVSFVFLLCIIAFvGIKMCKKDNGSSFIV---------------------------------------- 722  green anole
XP_016848536   681 TLTMYLVICLASVSFVFLLCIASFvGIKMCKKDHGSSFIV---------------------------------------- 720  green anole
DAA06588       683 TLTMYLVICLASVSFVFLLCIVSFiGIKICKKDHGSSFIA---------------------------------------- 722  green anole
XP_016161045   679 SLTTYLIIALVFVSLLFLISSALFvARKVCKSKELKAAHV---------------------------------------- 718  collared fly...
XP_002804241   792 sSnvpSNPAqVPVEES----------GGFGSHHhnQNYCYQVCLTPESAKTDLMFLK 838  Rhesus monkey
XP_003404856   730 ------fyddCNFPNNlv------qvRGNGSLS--QPCSYEMCSATGTGNSEFRFLK 772  African savanna elephant
XP_005209567   730 ------fyddCNFSNNlv------qgGASGPIL--QPCPYEMCSATGTSNSEFRFLK 772  cattle
ELW54080       730 ------fyddCNFPNNlv------qgGRNGSLS--QPCSYEMCSVTGTGNSEFRFLK 772  Chinese tree shrew
XP_016160885   732 pS---CYGD-GDFASSgm------gvGSTGTLS--PAYRYEMCLTSGSGRSEFQFLR 776  Collared flycatcher
20_pfamImport   41 ----------PTFPKSaa-------eSSAGSLP--RSYVYDVCFAAGTVNSEFHFLR 78  
XP_016848527   723 --------ApPHFPPArpdipenctdSQSGSLS--RNYQYDVCLTGGSLSSEFRFLR 769  green anole
XP_016848536   721 --------ApPHFPPAipen---csdSQSGSLS--RNYPYDVCLTNGTLSSEFRFLR 764  green anole
DAA06588       723 --------AaPQFPPPlpen---ctdSQSGSLS--RNYQYDVCLTNGSLTSDFRFLR 766  green anole
XP_016161045   719 ------LSGaHNLHSGla------daAAAGTLP--RAYCYEISLTTGSGNSEFQFLK 761  collared flycatcher
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