Format

Send to:

Choose Destination

FUT6 fucosyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 2528, updated on 26-Nov-2021

Summary

Official Symbol
FUT6provided by HGNC
Official Full Name
fucosyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:4017
See related
Ensembl:ENSG00000156413 MIM:136836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FT1A; FCT3A; Fuc-TVI; FucT-VI
Summary
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 17.3), esophagus (RPKM 12.2) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FUT6 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (5830408..5840019, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5830419..5838803, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11822 Neighboring gene neurturin Neighboring gene uncharacterized LOC101928844 Neighboring gene fucosyltransferase 3 (Lewis blood group) Neighboring gene fucosyltransferase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
GeneReviews: Not available
Fucosyltransferase 6 deficiency
MedGen: C3151219 OMIM: 613852 GeneReviews: Not available
Compare labs
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
GeneReviews: Not available
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
GeneReviews: Not available
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
GeneReviews: Not available

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • FLJ40754

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6
Names
alpha-(1,3)-fucosyltransferase 6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
fucosyltransferase VI
galactoside 3-L-fucosyltransferase
NP_000141.1
NP_001035791.1
NP_001356431.1
NP_001356433.1
NP_001356434.1
NP_001368884.1
NP_001368885.1
NP_001368886.1
NP_001368887.1
NP_001368888.1
XP_011526174.1
XP_011526177.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007505.1 RefSeqGene

    Range
    5001..14106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000150.4NP_000141.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

    See identical proteins and their annotated locations for NP_000141.1

    Status: REVIEWED

    Source sequence(s)
    AC024592
    Consensus CDS
    CCDS12152.1
    UniProtKB/Swiss-Prot
    P51993
    UniProtKB/TrEMBL
    Q6P7E6
    Related
    ENSP00000313398.4, ENST00000318336.10
    Conserved Domains (2) summary
    pfam00852
    Location:188351
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  2. NM_001040701.2NP_001035791.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

    See identical proteins and their annotated locations for NP_001035791.1

    Status: REVIEWED

    Source sequence(s)
    AC024592
    Consensus CDS
    CCDS12152.1
    UniProtKB/Swiss-Prot
    P51993
    UniProtKB/TrEMBL
    Q6P7E6
    Related
    ENSP00000286955.5, ENST00000286955.5
    Conserved Domains (2) summary
    pfam00852
    Location:188351
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  3. NM_001369502.1NP_001356431.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC024592, AF131211, DA426469
    Related
    ENSP00000432954.1, ENST00000527106.5
    Conserved Domains (2) summary
    pfam00852
    Location:188351
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  4. NM_001369504.1NP_001356433.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC024592, AF131211, AK098073, DA426469, DA761223
    Conserved Domains (2) summary
    pfam00852
    Location:188351
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  5. NM_001369505.1NP_001356434.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC024592, AF131211, DA426469, DA761273
    Conserved Domains (2) summary
    pfam00852
    Location:188351
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  6. NM_001381955.1NP_001368884.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC024592
    Conserved Domains (2) summary
    pfam00852
    Location:188351
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  7. NM_001381956.1NP_001368885.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC024592
    Conserved Domains (2) summary
    pfam00852
    Location:188351
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  8. NM_001381957.1NP_001368886.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC024592
    Related
    ENSP00000466016.1, ENST00000592563.1
    Conserved Domains (2) summary
    pfam00852
    Location:188350
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  9. NM_001381958.1NP_001368887.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC024592
    Conserved Domains (2) summary
    pfam00852
    Location:188350
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  10. NM_001381959.1NP_001368888.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC024592
    Conserved Domains (2) summary
    pfam00852
    Location:188350
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    5830408..5840019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527872.3XP_011526174.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

    See identical proteins and their annotated locations for XP_011526174.1

    UniProtKB/Swiss-Prot
    P51993
    Conserved Domains (2) summary
    pfam00852
    Location:188351
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  2. XM_011527875.3XP_011526177.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform X1

    See identical proteins and their annotated locations for XP_011526177.1

    UniProtKB/Swiss-Prot
    P51993
    Conserved Domains (2) summary
    pfam00852
    Location:188351
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
Support Center