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Chrm1 cholinergic receptor, muscarinic 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25229, updated on 13-Apr-2024

Summary

Official Symbol
Chrm1provided by RGD
Official Full Name
cholinergic receptor, muscarinic 1provided by RGD
Primary source
RGD:2342
See related
Ensembl:ENSRNOG00000018385 AllianceGenome:RGD:2342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; neuromuscular synaptic transmission; and positive regulation of intracellular protein transport. Located in several cellular components, including axon terminus; dendrite; and postsynaptic density. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 73.8) See more
Orthologs
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Genomic context

See Chrm1 in Genome Data Viewer
Location:
1q43
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (214996180..215012136)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205567226..205583001)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224869087..224885101)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22, member 25 Neighboring gene solute carrier family 22 member 6 Neighboring gene uncharacterized LOC134483966 Neighboring gene uncharacterized LOC100912041 Neighboring gene solute carrier family 3 member 2 Neighboring gene small nucleolar RNA, C/D box 26

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cognition IEA
Inferred from Electronic Annotation
more info
 
involved_in entrainment of circadian clock ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phototransduction, visible light ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of monoatomic ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of locomotion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in saliva secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
muscarinic acetylcholine receptor M1
Names
Cholinergic receptor, muscarin 1
m1 muscarinic acetylcholine receptor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080773.2NP_542951.1  muscarinic acetylcholine receptor M1

    See identical proteins and their annotated locations for NP_542951.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P08482
    UniProtKB/TrEMBL
    A6HZR8
    Related
    ENSRNOP00000024785.2, ENSRNOT00000024785.5
    Conserved Domains (1) summary
    cd17790
    Location:26429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    214996180..215012136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281373.1XP_063137443.1  muscarinic acetylcholine receptor M1 isoform X1

    UniProtKB/Swiss-Prot
    P08482
    UniProtKB/TrEMBL
    A6HZR8