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CHRM1 cholinergic receptor muscarinic 1 [ Homo sapiens (human) ]

Gene ID: 1128, updated on 20-Nov-2022

Summary

Official Symbol
CHRM1provided by HGNC
Official Full Name
cholinergic receptor muscarinic 1provided by HGNC
Primary source
HGNC:HGNC:1950
See related
Ensembl:ENSG00000168539 MIM:118510; AllianceGenome:HGNC:1950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M1; HM1; M1R
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 24.3), brain (RPKM 18.2) and 4 other tissues See more
Orthologs
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Genomic context

See CHRM1 in Genome Data Viewer
Location:
11q12.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62908679..62921878, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62898039..62910722, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62676151..62688835, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 1 Neighboring gene small nucleolar RNA, C/D box 25 Neighboring gene solute carrier family 3 member 2 Neighboring gene uncharacterized LOC124902683 Neighboring gene uncharacterized LOC105369333 Neighboring gene RNA, 7SL, cytoplasmic 259, pseudogene Neighboring gene solute carrier family 22 member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC30125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cognition IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuromuscular synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of glial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of locomotion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in saliva secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in axon terminus IEA
Inferred from Electronic Annotation
more info
 
located_in cholinergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
muscarinic acetylcholine receptor M1
Names
acetylcholine receptor, muscarinic 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000738.3NP_000729.2  muscarinic acetylcholine receptor M1

    See identical proteins and their annotated locations for NP_000729.2

    Status: REVIEWED

    Source sequence(s)
    BC022984
    Consensus CDS
    CCDS8040.1
    UniProtKB/Swiss-Prot
    P11229, Q96RH1
    UniProtKB/TrEMBL
    Q53XZ3
    Related
    ENSP00000306490.3, ENST00000306960.4
    Conserved Domains (1) summary
    cd17790
    Location:26429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62908679..62921878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544742.3XP_011543044.1  muscarinic acetylcholine receptor M1 isoform X1

    See identical proteins and their annotated locations for XP_011543044.1

    UniProtKB/Swiss-Prot
    P11229, Q96RH1
    UniProtKB/TrEMBL
    Q53XZ3
    Conserved Domains (1) summary
    cd17790
    Location:26429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62898039..62910722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)