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FUCA2 alpha-L-fucosidase 2 [ Homo sapiens (human) ]

Gene ID: 2519, updated on 18-Aug-2020

Summary

Official Symbol
FUCA2provided by HGNC
Official Full Name
alpha-L-fucosidase 2provided by HGNC
Primary source
HGNC:HGNC:4008
See related
Ensembl:ENSG00000001036 MIM:136820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ20N2.5
Summary
This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in placenta (RPKM 24.8), colon (RPKM 24.3) and 25 other tissues See more
Orthologs

Genomic context

See FUCA2 in Genome Data Viewer
Location:
6q24.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (143494812..143511720, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (143815949..143833020, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adenosine deaminase tRNA specific 2 Neighboring gene RNA, 5S ribosomal pseudogene 221 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene voltage dependent anion channel 1 pseudogene 8 Neighboring gene uncharacterized LOC105378035 Neighboring gene PHACTR2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of fucosidase, alpha-L- 2, plasma (FUCA2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1314

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-L-fucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-L-fucosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
fucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycoside catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of entry of bacterium into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
plasma alpha-L-fucosidase
Names
I+/--L-fucosidase 2
a-L-fucosidase 2
alpha-L-fucoside fucohydrolase 2
fucosidase, alpha-L- 2, plasma
plasma fucosidase
NP_114409.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027676.1 RefSeqGene

    Range
    5164..22072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032020.5NP_114409.2  plasma alpha-L-fucosidase precursor

    See identical proteins and their annotated locations for NP_114409.2

    Status: REVIEWED

    Source sequence(s)
    AK315475, AL031320, BC003060, BP214015
    Consensus CDS
    CCDS5200.1
    UniProtKB/Swiss-Prot
    Q9BTY2
    Related
    ENSP00000002165.5, ENST00000002165.11
    Conserved Domains (3) summary
    smart00812
    Location:28413
    Alpha_L_fucos; Alpha-L-fucosidase
    COG3669
    Location:60429
    AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]
    pfam16757
    Location:376464
    Fucosidase_C; Alpha-L-fucosidase C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    143494812..143511720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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