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ALPP alkaline phosphatase, placental [ Homo sapiens (human) ]

Gene ID: 250, updated on 8-Dec-2018

Summary

Official Symbol
ALPPprovided by HGNC
Official Full Name
alkaline phosphatase, placentalprovided by HGNC
Primary source
HGNC:HGNC:439
See related
Ensembl:ENSG00000163283 MIM:171800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALP; IAP; ALPI; PALP; PLAP; PLAP-1
Summary
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]
Expression
Restricted expression toward placenta (RPKM 36.6) See more
Orthologs

Genomic context

See ALPP in Genome Data Viewer
Location:
2q37.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (232378534..232382889)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233243348..233247599)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene DIS3 like 3'-5' exoribonuclease 2 Neighboring gene nuclear receptor binding factor 2 pseudogene Neighboring gene endothelin converting enzyme like 1 pseudogene 3 Neighboring gene uncharacterized LOC107985999 Neighboring gene endothelin converting enzyme like 1 pseudogene 2 Neighboring gene alkaline phosphatase, germ cell

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cells exposed in vitro to HIV-1 gp120 show a defect in inositol polyphosphate-mediated signal transduction resulting from the downregulation of inositol (1,3,4,5)P4 5-phosphomonoesterase (PME) by gp120 PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with alkaline phosphatase, placental (ALPP; PLAP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ61142

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
alkaline phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
alkaline phosphatase, placental type
Names
Intestinal alkaline phosphatase
Intestinal-type alkaline phosphatase
alkaline phosphatase Regan isozyme
alkaline phosphomonoesterase
glycerophosphatase
placental alkaline phosphatase 1
NP_001623.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012189.1 RefSeqGene

    Range
    4897..9252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001632.5NP_001623.3  alkaline phosphatase, placental type preproprotein

    See identical proteins and their annotated locations for NP_001623.3

    Status: REVIEWED

    Source sequence(s)
    AF217992, BC009647, BC094743
    Consensus CDS
    CCDS2490.1
    UniProtKB/Swiss-Prot
    P05187
    UniProtKB/TrEMBL
    B2R7C7
    Related
    ENSP00000375881.2, ENST00000392027.2
    Conserved Domains (2) summary
    PRK10518
    Location:28478
    PRK10518; alkaline phosphatase; Provisional
    pfam00245
    Location:55490
    Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    232378534..232382889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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