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FSHB follicle stimulating hormone subunit beta [ Homo sapiens (human) ]

Gene ID: 2488, updated on 25-Nov-2021

Summary

Official Symbol
FSHBprovided by HGNC
Official Full Name
follicle stimulating hormone subunit betaprovided by HGNC
Primary source
HGNC:HGNC:3964
See related
Ensembl:ENSG00000131808 MIM:136530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH24
Summary
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See FSHB in Genome Data Viewer
Location:
11p14.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (30231014..30235194)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (30252561..30256741)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984321 Neighboring gene potassium voltage-gated channel subfamily A member 4 Neighboring gene ARL14EP divergent transcript Neighboring gene ADP ribosylation factor like GTPase 14 effector protein Neighboring gene uncharacterized LOC102723403

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hypogonadotropic hypogonadism 24 without anosmia
MedGen: C1856716 OMIM: 229070 GeneReviews: Not available
Compare labs
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables follicle-stimulating hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables follicle-stimulating hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables follicle-stimulating hormone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Sertoli cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in female gamete generation TAS
Traceable Author Statement
more info
PubMed 
involved_in female pregnancy TAS
Traceable Author Statement
more info
PubMed 
involved_in follicle-stimulating hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of steroid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in progesterone biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in transforming growth factor beta receptor signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of follicle-stimulating hormone complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of follicle-stimulating hormone complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
follitropin subunit beta
Names
FSH-B
FSH-beta
follicle stimulating hormone beta subunit
follicle stimulating hormone, beta polypeptide
follitropin, beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008144.1 RefSeqGene

    Range
    4999..9262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000510.4NP_000501.1  follitropin subunit beta precursor

    See identical proteins and their annotated locations for NP_000501.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AL358944, BI033915, CD108062
    Consensus CDS
    CCDS7868.1
    UniProtKB/Swiss-Prot
    P01225
    UniProtKB/TrEMBL
    A0A0F7RQE8
    Related
    ENSP00000254122.3, ENST00000254122.8
    Conserved Domains (1) summary
    smart00068
    Location:17123
    GHB; Glycoprotein hormone beta chain homologues
  2. NM_001018080.3NP_001018090.1  follitropin subunit beta precursor

    See identical proteins and their annotated locations for NP_001018090.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AL358944, BI033915, CD108062
    Consensus CDS
    CCDS7868.1
    UniProtKB/Swiss-Prot
    P01225
    UniProtKB/TrEMBL
    A0A0F7RQE8
    Related
    ENSP00000416606.1, ENST00000417547.1
    Conserved Domains (1) summary
    smart00068
    Location:17123
    GHB; Glycoprotein hormone beta chain homologues
  3. NM_001382289.1NP_001369218.1  follitropin subunit beta precursor

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AL358944
    Related
    ENSP00000433424.1, ENST00000533718.2
    Conserved Domains (1) summary
    smart00068
    Location:17123
    GHB; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    30231014..30235194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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