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Fshb follicle stimulating hormone beta [ Mus musculus (house mouse) ]

Gene ID: 14308, updated on 21-Apr-2024

Summary

Official Symbol
Fshbprovided by MGI
Official Full Name
follicle stimulating hormone betaprovided by MGI
Primary source
MGI:MGI:95582
See related
Ensembl:ENSMUSG00000027120 AllianceGenome:MGI:95582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FSH; FSH-B; Fshbeta; FSH-beta
Summary
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

Location:
2 E3; 2 56.02 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (106886331..106889996, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (107055986..107059651, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05332 Neighboring gene STARR-seq mESC enhancer starr_05333 Neighboring gene ADP-ribosylation factor-like 14 effector protein Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05336 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 4 Neighboring gene STARR-seq mESC enhancer starr_05337 Neighboring gene STARR-seq mESC enhancer starr_05338 Neighboring gene predicted gene, 39903

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables follicle-stimulating hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables follicle-stimulating hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of follicle-stimulating hormone complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
follitropin subunit beta
Names
follicle-stimulating hormone beta subunit
follitropin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008045.3NP_032071.1  follitropin subunit beta precursor

    See identical proteins and their annotated locations for NP_032071.1

    Status: REVIEWED

    Source sequence(s)
    BB020786, BB026460, BC061159
    Consensus CDS
    CCDS16504.1
    UniProtKB/Swiss-Prot
    Q60687
    UniProtKB/TrEMBL
    A0A0F7RQR1
    Related
    ENSMUSP00000028533.7, ENSMUST00000028533.7
    Conserved Domains (1) summary
    smart00068
    Location:18124
    GHB; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    106886331..106889996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)