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ALPI alkaline phosphatase, intestinal [ Homo sapiens (human) ]

Gene ID: 248, updated on 12-Aug-2018

Summary

Official Symbol
ALPIprovided by HGNC
Official Full Name
alkaline phosphatase, intestinalprovided by HGNC
Primary source
HGNC:HGNC:437
See related
Ensembl:ENSG00000163295 MIM:171740; Vega:OTTHUMG00000133258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IAP
Summary
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]
Expression
Biased expression in duodenum (RPKM 85.5), small intestine (RPKM 83.4) and 1 other tissue See more
Orthologs

Genomic context

See ALPI in Genome Data Viewer
Location:
2q37.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (232456112..232460745)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233320833..233325455)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene endothelin converting enzyme like 1 pseudogene 1 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 pseudogene 1 Neighboring gene endothelin converting enzyme like 1 Neighboring gene serine protease 56

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cells exposed in vitro to HIV-1 gp120 show a defect in inositol polyphosphate-mediated signal transduction resulting from the downregulation of inositol (1,3,4,5)P4 5-phosphomonoesterase (PME) by gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alkaline phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
alkaline phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
alkaline phosphatase activity TAS
Traceable Author Statement
more info
 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
digestion TAS
Traceable Author Statement
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
intestinal-type alkaline phosphatase
Names
Kasahara isozyme
alkaline phosphomonoesterase
glycerophosphatase
intestinal alkaline phosphatase
NP_001622.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001631.4NP_001622.2  intestinal-type alkaline phosphatase precursor

    See identical proteins and their annotated locations for NP_001622.2

    Status: REVIEWED

    Source sequence(s)
    AC068134, BC132678, DA376676
    Consensus CDS
    CCDS2492.1
    UniProtKB/Swiss-Prot
    P09923
    UniProtKB/TrEMBL
    A0A024R4A2
    Related
    ENSP00000295463.3, OTTHUMP00000164357, ENST00000295463.3, OTTHUMT00000257035
    Conserved Domains (1) summary
    pfam00245
    Location:52487
    Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    232456112..232460745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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