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Naxe NAD(P)HX epimerase [ Mus musculus (house mouse) ]

Gene ID: 246703, updated on 13-Dec-2022

Summary

Official Symbol
Naxeprovided by MGI
Official Full Name
NAD(P)HX epimeraseprovided by MGI
Primary source
MGI:MGI:2180167
See related
Ensembl:ENSMUSG00000028070 AllianceGenome:MGI:2180167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIBP; AI-BP; ESTM37; Apoa1bp; Apoa1ip
Summary
Enables identical protein binding activity. Predicted to be involved in several processes, including membrane raft distribution; negative regulation of angiogenesis; and regulation of cholesterol efflux. Predicted to act upstream of or within lipid transport. Located in several cellular components, including cell body; extracellular space; and mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and skeletal muscle tissue. Orthologous to human NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 55.9), adrenal adult (RPKM 49.5) and 28 other tissues See more
Orthologs
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Genomic context

See Naxe in Genome Data Viewer
Location:
3; 3 F1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87963827..87965851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88056520..88058542, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19439 Neighboring gene G patch domain containing 4 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene IQ motif containing GTPase activating protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADHX epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADHX epimerase activity ISO
Inferred from Sequence Orthology
more info
 
enables NADPHX epimerase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane raft distribution ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in nicotinamide nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
NAD(P)H-hydrate epimerase
Names
apoA-I binding protein
apolipoprotein A-I binding protein
apolipoprotein A-I interacting protein
NP_659146.1
XP_006501580.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409767.1NP_001396696.1  NAD(P)H-hydrate epimerase isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  2. NM_001409768.1NP_001396697.1  NAD(P)H-hydrate epimerase isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  3. NM_001409770.1NP_001396699.1  NAD(P)H-hydrate epimerase isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  4. NM_001409771.1NP_001396700.1  NAD(P)H-hydrate epimerase isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  5. NM_001409773.1NP_001396702.1  NAD(P)H-hydrate epimerase isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  6. NM_001409774.1NP_001396703.1  NAD(P)H-hydrate epimerase isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  7. NM_001409775.1NP_001396704.1  NAD(P)H-hydrate epimerase isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  8. NM_001409776.1NP_001396705.1  NAD(P)H-hydrate epimerase isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  9. NM_001409777.1NP_001396706.1  NAD(P)H-hydrate epimerase isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  10. NM_001409778.1NP_001396707.1  NAD(P)H-hydrate epimerase isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525
  11. NM_001409779.1NP_001396708.1  NAD(P)H-hydrate epimerase isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC137525
  12. NM_001409780.1NP_001396709.1  NAD(P)H-hydrate epimerase isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC137525
  13. NM_144897.4NP_659146.1  NAD(P)H-hydrate epimerase isoform 2 precursor

    See identical proteins and their annotated locations for NP_659146.1

    Status: VALIDATED

    Source sequence(s)
    AC137525
    Consensus CDS
    CCDS17464.1
    UniProtKB/Swiss-Prot
    Q8K4Z3
    UniProtKB/TrEMBL
    A0A8C6IN19
    Related
    ENSMUSP00000029708.7, ENSMUST00000029708.8
    Conserved Domains (1) summary
    cl00318
    Location:46281
    YjeF_N; YjeF-related protein N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87963827..87965851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501517.5XP_006501580.2  NAD(P)H-hydrate epimerase isoform X1

    Conserved Domains (1) summary
    PLN03049
    Location:50167
    PLN03049; pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional

RNA

  1. XR_004941327.1 RNA Sequence