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NAXE NAD(P)HX epimerase [ Homo sapiens (human) ]

Gene ID: 128240, updated on 22-Aug-2020

Summary

Official Symbol
NAXEprovided by HGNC
Official Full Name
NAD(P)HX epimeraseprovided by HGNC
Primary source
HGNC:HGNC:18453
See related
Ensembl:ENSG00000163382 MIM:608862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIBP; PEBEL; YJEFN1; APOA1BP
Summary
The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 11.3), prostate (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See NAXE in Genome Data Viewer
Location:
1q22
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156591776..156599818)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156561554..156564091)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 3 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene G-patch domain containing 4 Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene uncharacterized LOC101928177 Neighboring gene BCAN antisense RNA 1 Neighboring gene brevican

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119143, MGC119144, MGC119145

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADHX epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADPHX epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
 
membrane raft distribution IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
nicotinamide nucleotide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell body IEA
Inferred from Electronic Annotation
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
NAD(P)H-hydrate epimerase
Names
AI-BP
apoA-I binding protein
apolipoprotein A-I-binding protein
yjeF N-terminal domain-containing protein 1
yjeF_N1
NP_658985.2
XP_016855808.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052542.1 RefSeqGene

    Range
    5011..7534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144772.3NP_658985.2  NAD(P)H-hydrate epimerase precursor

    See identical proteins and their annotated locations for NP_658985.2

    Status: REVIEWED

    Source sequence(s)
    AL365181, BC100933, BG723681, BQ430064
    Consensus CDS
    CCDS1145.1
    UniProtKB/Swiss-Prot
    Q8NCW5
    Related
    ENSP00000357218.3, ENST00000368235.8
    Conserved Domains (1) summary
    cl00318
    Location:52287
    YjeF_N; YjeF-related protein N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156591776..156599818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000319.2XP_016855808.1  NAD(P)H-hydrate epimerase isoform X1

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