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Plcd1 phospholipase C, delta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24655, updated on 2-May-2024

Summary

Official Symbol
Plcd1provided by RGD
Official Full Name
phospholipase C, delta 1provided by RGD
Primary source
RGD:3346
See related
Ensembl:ENSRNOG00000032238 AllianceGenome:RGD:3346
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Plc1
Summary
Enables several functions, including inositol 1,4,5 trisphosphate binding activity; phosphatidylinositol phospholipase C activity; and phospholipid binding activity. Involved in several processes, including positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; and positive regulation of norepinephrine secretion. Located in several cellular components, including cytosol; membrane raft; and mitochondrial membrane. Used to study congestive heart failure and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 103.2), Muscle (RPKM 72.4) and 9 other tissues See more
Orthologs
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Genomic context

See Plcd1 in Genome Data Viewer
Location:
8q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127672955..127695939, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118795196..118818186, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127753514..127782070, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase like Neighboring gene microRNA 26a Neighboring gene villin-like Neighboring gene uncharacterized LOC102548352 Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene acetyl-Coenzyme A acyltransferase 1B Neighboring gene solute carrier family 22, member 14

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activating protein binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium-dependent phospholipid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables inositol 1,4,5 trisphosphate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inositol trisphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of norepinephrine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to aluminum ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to prostaglandin F IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Names
PLC-III
PLC-delta-1
Phospholipase C-delta1
phosphoinositide phospholipase C
phosphoinositide phospholipase C-delta-1
phospholipase C delta 1 long form
phospholipase C-III
NP_058731.2
XP_006244125.1
XP_038936754.1
XP_038936755.1
XP_038936756.1
XP_038936757.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017035.2NP_058731.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P10688, Q80WI4, Q9QVD3, Q9QVD4, Q9QVD5
    UniProtKB/TrEMBL
    A6I3V0, G3V9D1
    Related
    ENSRNOP00000042824.3, ENSRNOT00000045493.6
    Conserved Domains (4) summary
    cd00275
    Location:628755
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08593
    Location:295596
    PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
    cd13363
    Location:22139
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16217
    Location:144283
    EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    127672955..127695939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244063.5XP_006244125.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0I7, A6Y857
    Related
    ENSRNOP00000076591.1
    Conserved Domains (7) summary
    cd00275
    Location:628782
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08593
    Location:295596
    PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
    PLN02952
    Location:213778
    PLN02952; phosphoinositide phospholipase C
    cd13363
    Location:22139
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:30130
    PH; PH domain
    pfam09279
    Location:213295
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam14788
    Location:159208
    EF-hand_10; EF hand
  2. XM_039080826.2XP_038936754.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2

    UniProtKB/Swiss-Prot
    P10688, Q80WI4, Q9QVD3, Q9QVD4, Q9QVD5
    UniProtKB/TrEMBL
    A0A8I6GIK0
    Related
    ENSRNOP00000090035.1
    Conserved Domains (4) summary
    cd00275
    Location:654781
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08593
    Location:321622
    PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
    cd13363
    Location:48165
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16217
    Location:170309
    EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)
  3. XM_039080828.1XP_038936756.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X4

    Conserved Domains (3) summary
    cd00275
    Location:372499
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08593
    Location:39340
    PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
    pfam09279
    Location:832
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  4. XM_039080829.2XP_038936757.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X5

    Conserved Domains (3) summary
    cd13363
    Location:22139
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16217
    Location:144283
    EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)
    cl14615
    Location:295430
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  5. XM_039080827.2XP_038936755.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X3

    Conserved Domains (3) summary
    cd13363
    Location:48165
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16217
    Location:170309
    EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)
    cl14615
    Location:321456
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily