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Ovca2 candidate tumor suppressor in ovarian cancer 2 [ Mus musculus (house mouse) ]

Gene ID: 246257, updated on 11-Apr-2024

Summary

Official Symbol
Ovca2provided by MGI
Official Full Name
candidate tumor suppressor in ovarian cancer 2provided by MGI
Primary source
MGI:MGI:2179725
See related
Ensembl:ENSMUSG00000038268 AllianceGenome:MGI:2179725
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030414M07Rik
Summary
Predicted to enable hydrolase activity. Predicted to be involved in response to retinoic acid. Located in cytoplasm and nucleus. Orthologous to human OVCA2 (OVCA2 serine hydrolase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.2), kidney adult (RPKM 10.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ovca2 in Genome Data Viewer
Location:
11 B5; 11 45.76 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75066769..75069634, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75175943..75178808, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700016P03 gene Neighboring gene microRNA 212 Neighboring gene microRNA 132 Neighboring gene STARR-positive B cell enhancer ABC_E7016 Neighboring gene diphthamide biosynthesis 1 Neighboring gene reticulon 4 receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_29983 Neighboring gene STARR-seq mESC enhancer starr_29985 Neighboring gene STARR-seq mESC enhancer starr_29986 Neighboring gene predicted gene, 35169 Neighboring gene predicted gene, 35117

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in response to retinoic acid IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
esterase OVCA2
Names
candidate tumor suppressor OVCA2
ortholog of human candidate tumor suppressor in ovarian cancer 2 OVCA2
ovarian cancer-associated gene 2 protein homolog
NP_081412.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027136.3NP_081412.1  esterase OVCA2

    See identical proteins and their annotated locations for NP_081412.1

    Status: PROVISIONAL

    Source sequence(s)
    AL603905
    Consensus CDS
    CCDS25041.1
    UniProtKB/Swiss-Prot
    Q9D7E3
    Related
    ENSMUSP00000071493.3, ENSMUST00000071562.3
    Conserved Domains (1) summary
    pfam03959
    Location:6216
    FSH1; Serine hydrolase (FSH1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75066769..75069634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)