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OVCA2 OVCA2 serine hydrolase domain containing [ Homo sapiens (human) ]

Gene ID: 124641, updated on 6-Sep-2022

Summary

Official Symbol
OVCA2provided by HGNC
Official Full Name
OVCA2 serine hydrolase domain containingprovided by HGNC
Primary source
HGNC:HGNC:24203
See related
Ensembl:ENSG00000262664 MIM:607896; AllianceGenome:HGNC:24203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in response to retinoic acid. Located in cytoplasm. Biomarker of ovarian cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 23.0), gall bladder (RPKM 21.3) and 25 other tissues See more
Orthologs
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Genomic context

See OVCA2 in Genome Data Viewer
Location:
17p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (2042022..2043425)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (1929929..1931332)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1945316..1946719)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene replication protein A1 Neighboring gene succinate dehydrogenase complex subunit C pseudogene Neighboring gene reticulon 4 receptor like 1 Neighboring gene uncharacterized LOC105371486 Neighboring gene uncharacterized LOC105371485 Neighboring gene uncharacterized LOC124903896 Neighboring gene diphthamide biosynthesis 1 Neighboring gene microRNA 132 Neighboring gene microRNA 212

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in response to retinoic acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
esterase OVCA2
Names
candidate tumor suppressor in ovarian cancer 2
ovarian cancer gene-2 protein
ovarian cancer-associated gene 2 protein
ovarian tumor suppressor candidate 2
NP_543012.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080822.3NP_543012.1  esterase OVCA2

    See identical proteins and their annotated locations for NP_543012.1

    Status: VALIDATED

    Source sequence(s)
    BC041170, CB137429
    Consensus CDS
    CCDS11015.1
    UniProtKB/Swiss-Prot
    Q8WZ82, Q9UCX9
    Related
    ENSP00000461388.1, ENST00000572195.3
    Conserved Domains (1) summary
    pfam03959
    Location:5218
    FSH1; Serine hydrolase (FSH1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    2042022..2043425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    1929929..1931332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)