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Adipoq adiponectin, C1Q and collagen domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 246253, updated on 1-Oct-2018

Summary

Official Symbol
Adipoqprovided by RGD
Official Full Name
adiponectin, C1Q and collagen domain containingprovided by RGD
Primary source
RGD:628748
See related
Ensembl:ENSRNOG00000001821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acdc; Adid; Acrp30
Summary
adipocyte complement-related factor that plays a role in obesity-related insulin resistance [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 1195.4), Thymus (RPKM 913.1) and 5 other tissues See more
Orthologs

Genomic context

See Adipoq in Genome Data Viewer
Location:
11q23
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (81330845..81344488, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (84363940..84382663, complement)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Neighboring gene uncharacterized LOC108352356 Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene replication factor C subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
    AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, conserved biosystem (from KEGG)
    Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
hormone activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sialic acid binding IEA
Inferred from Electronic Annotation
more info
 
sialic acid binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to epinephrine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
detection of oxidative stress ISO
Inferred from Sequence Orthology
more info
 
detection of oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid oxidation NAS
Non-traceable Author Statement
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of granulocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of heterotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of low-density lipoprotein particle receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of low-density lipoprotein particle receptor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage derived foam cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of metanephric mesenchymal cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of metanephric mesenchymal cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet-derived growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular associated smooth muscle cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glycogen (starch) synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of metanephric glomerular visceral epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric glomerular visceral epithelial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte chemotactic protein-1 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myeloid cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase A signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of renal albumin absorption ISO
Inferred from Sequence Orthology
more info
 
positive regulation of renal albumin absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterotrimerization IEA
Inferred from Electronic Annotation
more info
 
protein heterotrimerization ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
response to bacterium ISO
Inferred from Sequence Orthology
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucose ISO
Inferred from Sequence Orthology
more info
 
response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to linoleic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to sucrose IEP
Inferred from Expression Pattern
more info
PubMed 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell periphery ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adiponectin
Names
adipocyte complement related protein of 30 kDa
adiponectin d

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144744.3NP_653345.1  adiponectin precursor

    See identical proteins and their annotated locations for NP_653345.1

    Status: VALIDATED

    Source sequence(s)
    AC120949, FM047633
    UniProtKB/TrEMBL
    Q8K3R4
    Related
    ENSRNOP00000002492.3, ENSRNOT00000002492.5
    Conserved Domains (2) summary
    smart00110
    Location:109242
    C1Q; Complement component C1q domain
    pfam01391
    Location:42107
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    81330845..81344488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    76596543..76599824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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