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Adipoq adiponectin, C1Q and collagen domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 246253, updated on 25-Jan-2022

Summary

Official Symbol
Adipoqprovided by RGD
Official Full Name
adiponectin, C1Q and collagen domain containingprovided by RGD
Primary source
RGD:628748
See related
Ensembl:ENSRNOG00000001821 AllianceGenome:RGD:628748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acdc; Adid; Acrp30
Summary
Enables identical protein binding activity. Involved in several processes, including cellular response to organonitrogen compound; positive regulation of glycogen (starch) synthase activity; and positive regulation of protein phosphorylation. Located in extracellular space. Part of protein-containing complex. Used to study brain infarction. Biomarker of several diseases, including end stage renal disease; fatty liver disease (multiple); glucose metabolism disease (multiple); hyperthyroidism; and obesity. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Adrenal (RPKM 1195.4), Thymus (RPKM 913.1) and 5 other tissues See more
Orthologs
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Genomic context

See Adipoq in Genome Data Viewer
Location:
11q23
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (77721912..77735644, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (81330845..81344488, complement)

Chromosome 11 - NC_051346.1Genomic Context describing neighboring genes Neighboring gene ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Neighboring gene uncharacterized LOC102549362 Neighboring gene uncharacterized LOC120095690 Neighboring gene small nucleolar RNA SNORA4 Neighboring gene replication factor C subunit 4 Neighboring gene eukaryotic translation initiation factor 4A2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sialic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to epinephrine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in detection of oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid oxidation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within_positive_effect gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of granulocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heterotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of low-density lipoprotein receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage derived foam cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of metanephric mesenchymal cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of metanephric mesenchymal cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within positive regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of glycogen (starch) synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of lipid transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of metanephric glomerular visceral epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of metanephric glomerular visceral epithelial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte chemotactic protein-1 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myeloid cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase A signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of renal albumin absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of renal albumin absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to linoleic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to sucrose IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell periphery ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adiponectin
Names
adipocyte complement related protein of 30 kDa
adiponectin d

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144744.3NP_653345.1  adiponectin precursor

    See identical proteins and their annotated locations for NP_653345.1

    Status: VALIDATED

    Source sequence(s)
    FM047633, JACYVU010000222
    UniProtKB/TrEMBL
    Q8K3R4
    Related
    ENSRNOP00000002492.3, ENSRNOT00000002492.6
    Conserved Domains (2) summary
    smart00110
    Location:109242
    C1Q; Complement component C1q domain
    pfam01391
    Location:42107
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051346.1 Reference mRatBN7.2 Primary Assembly

    Range
    77721912..77735644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087986.1XP_038943914.1  adiponectin isoform X1

    Related
    ENSRNOP00000074467.1, ENSRNOT00000089988.2
    Conserved Domains (2) summary
    pfam01391
    Location:51107
    Collagen; Collagen triple helix repeat (20 copies)
    cl23878
    Location:109206
    C1q; C1q domain
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