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Adipoq adiponectin, C1Q and collagen domain containing [ Mus musculus (house mouse) ]

Gene ID: 11450, updated on 1-Mar-2024

Summary

Official Symbol
Adipoqprovided by MGI
Official Full Name
adiponectin, C1Q and collagen domain containingprovided by MGI
Primary source
MGI:MGI:106675
See related
Ensembl:ENSMUSG00000022878 AllianceGenome:MGI:106675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ad; APN; Acdc; Adid; apM1; 30kDa; GBP28; adipo; Acrp30
Summary
Enables hormone activity and identical protein binding activity. Involved in several processes, including detection of oxidative stress; negative regulation of cold-induced thermogenesis; and regulation of protein serine/threonine kinase activity. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including brown fat cell differentiation; negative regulation of gluconeogenesis; and positive regulation of glucose import. Located in endoplasmic reticulum and extracellular space. Is expressed in several structures, including adipose tissue; axial musculature; gut; male reproductive gland or organ; and serum. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 1033.0), mammary gland adult (RPKM 560.0) and 3 other tissues See more
Orthologs
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Genomic context

See Adipoq in Genome Data Viewer
Location:
16 B1; 16 13.96 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22965286..22976718)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23146536..23157968)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene predicted gene, 24616 Neighboring gene replication factor C (activator 1) 4 Neighboring gene STARR-positive B cell enhancer ABC_E8623 Neighboring gene adiponectin enhancer region Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:23165651-23165889 Neighboring gene RIKEN cDNA C730014E05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:23181839-23182022 Neighboring gene predicted pseudogene 6630 Neighboring gene predicted gene 15746

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sialic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to insulin stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within_positive_effect gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of low-density lipoprotein receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of metanephric mesenchymal cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of glucose import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of metanephric podocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of renal albumin absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of renal albumin absorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to glucose IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adiponectin
Names
30 kDa adipocyte complement-related protein
adipocyte complement related protein
adipocyte complement-related 30 kDa protein
adipocyte, C1Q and collagen domain containing
adipocyte, C1q and collagen domain-containing protein
adipocyte-specific protein AdipoQ
adiponectin d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009605.5NP_033735.3  adiponectin precursor

    See identical proteins and their annotated locations for NP_033735.3

    Status: VALIDATED

    Source sequence(s)
    AK134112
    Consensus CDS
    CCDS28075.1
    UniProtKB/Swiss-Prot
    Q60994, Q62400, Q6GTX4, Q9DC68
    UniProtKB/TrEMBL
    Q8BRW2
    Related
    ENSMUSP00000023593.6, ENSMUST00000023593.6
    Conserved Domains (2) summary
    smart00110
    Location:112245
    C1Q; Complement component C1q domain
    pfam01391
    Location:45107
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    22965286..22976718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)