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Gzmn granzyme N [ Mus musculus (house mouse) ]

Gene ID: 245839, updated on 8-Feb-2024

Summary

Official Symbol
Gzmnprovided by MGI
Official Full Name
granzyme Nprovided by MGI
Primary source
MGI:MGI:2675494
See related
Ensembl:ENSMUSG00000015443 AllianceGenome:MGI:2675494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GrN
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptosis. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human GZMB (granzyme B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 22.5) See more
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Genomic context

See Gzmn in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56403243..56412069, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56165786..56174612, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene predicted gene, 57616 Neighboring gene predicted gene 8961 Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene STARR-seq mESC enhancer starr_36793 Neighboring gene predicted gene, 57615

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytolytic granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305808.2NP_001292737.1  granzyme N isoform 1 precursor

    See identical proteins and their annotated locations for NP_001292737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC091783
    Consensus CDS
    CCDS88673.1
    UniProtKB/TrEMBL
    Q76HN3
    Related
    ENSMUSP00000153137.2, ENSMUST00000225535.2
    Conserved Domains (2) summary
    smart00020
    Location:20195
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:21194
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_153052.3NP_694692.1  granzyme N isoform 2 precursor

    See identical proteins and their annotated locations for NP_694692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC091783
    Consensus CDS
    CCDS27145.1
    UniProtKB/TrEMBL
    Q920S1
    Related
    ENSMUSP00000015587.8, ENSMUST00000015587.9
    Conserved Domains (2) summary
    smart00020
    Location:20241
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:21244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56403243..56412069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519020.2XP_006519083.1  granzyme N isoform X1

    Conserved Domains (1) summary
    cd00190
    Location:5228
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_017316021.2XP_017171510.1  granzyme N isoform X3

    Conserved Domains (1) summary
    cd00190
    Location:21114
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_017316020.1XP_017171509.1  granzyme N isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:21114
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...