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Mbl1 mannose binding lectin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24548, updated on 29-Feb-2024

Summary

Official Symbol
Mbl1provided by RGD
Official Full Name
mannose binding lectin 1provided by RGD
Primary source
RGD:3055
See related
Ensembl:ENSRNOG00000011706 AllianceGenome:RGD:3055
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mbpa; Mlb1
Summary
Enables several functions, including calcium-dependent carbohydrate binding activity; mannose binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in complement activation, lectin pathway and protein homotrimerization. Located in extracellular space. Orthologous to human MBL1P (mannose binding lectin 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 1232.3) See more
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Genomic context

Location:
16p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17063232..17069271)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17029146..17035187)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (18736154..18742193)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene pleckstrin homology and FYVE domain containing 2, pseudogene 2 Neighboring gene surfactant protein D Neighboring gene HAUS augmin-like complex, subunit 8 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mannose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oligosaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables polysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
mannose-binding protein A
Names
MBP-A
Mannose binding protein A, serum
mannan-binding protein
mannose binding lectin (A)
mannose binding lectin 1, protein A
mannose binding lectin 2, protein C
mannose-binding lectin (protein A) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012599.2NP_036731.2  mannose-binding protein A precursor

    See identical proteins and their annotated locations for NP_036731.2

    Status: PROVISIONAL

    Source sequence(s)
    BC088159
    UniProtKB/Swiss-Prot
    P19999
    UniProtKB/TrEMBL
    A6K9L8
    Related
    ENSRNOP00000015723.2, ENSRNOT00000015723.7
    Conserved Domains (2) summary
    cd03591
    Location:126236
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:3686
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    17063232..17069271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094193.2XP_038950121.1  mannose-binding protein A isoform X1

    UniProtKB/TrEMBL
    A6K9L9
    Conserved Domains (1) summary
    cd03591
    Location:29139
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)