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Layn layilin [ Mus musculus (house mouse) ]

Gene ID: 244864, updated on 18-Sep-2024

Summary

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Official Symbol
Laynprovided by MGI
Official Full Name
layilinprovided by MGI
Primary source
MGI:MGI:2685357
See related
Ensembl:ENSMUSG00000060594 AllianceGenome:MGI:2685357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm511; E030012M19Rik
Summary
Predicted to enable hyaluronic acid binding activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain and trigeminal ganglion. Orthologous to human LAYN (layilin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.6), ovary adult (RPKM 1.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Layn in Genome Data Viewer
Location:
9 A5.3; 9 27.79 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50966323..50988501, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (51055023..51077209, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene predicted gene, 25558 Neighboring gene salt inducible kinase 2 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene microRNA 34b Neighboring gene BTG anti-proliferation factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Layilin Anchors Regulatory T Cells in Skin. Mehta P, et al. J Immunol, 2021 Oct 1. PMID 34470859, Free PMC Article
  2. Layilin augments integrin activation to promote antitumor immunity. Mahuron KM, et al. J Exp Med, 2020 Sep 7. PMID 32539073, Free PMC Article
  3. Layilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo. Kim Y, et al. Matrix Biol, 2018 Mar. PMID 28978412, Free PMC Article
  4. Roles of layilin in TNF-α-induced epithelial-mesenchymal transformation of renal tubular epithelial cells. Adachi T, et al. Biochem Biophys Res Commun, 2015 Nov 6. PMID 26410531
  5. Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain. Wegener KL, et al. J Mol Biol, 2008 Sep 26. PMID 18638481

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Layilin Anchors Regulatory T Cells in Skin.
    Title: Layilin Anchors Regulatory T Cells in Skin.
  2. Layilin augments integrin activation to promote antitumor immunity.
    Title: Layilin augments integrin activation to promote antitumor immunity.
  3. LAYN is involved in the TNF-alpha-induced epithelial-mesenchymal transformation (EMT) of renal tubular epithelial cells.
    Title: Roles of layilin in TNF-α-induced epithelial-mesenchymal transformation of renal tubular epithelial cells.
  4. The structure of the talin/layilin complex, which shows that talin binds integrins, PIPK1gamma and layilin in similar although subtly different ways, is reported.
    Title: Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables hyaluronic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
layilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033534.1 → NP_001028706.1  layilin precursor

    See identical proteins and their annotated locations for NP_001028706.1

    Status: VALIDATED

    Source sequence(s)
    AC119831
    Consensus CDS
    CCDS52791.1
    UniProtKB/Swiss-Prot
    E9QQ23, Q3TMU7, Q8C351
    UniProtKB/TrEMBL
    A4QPF5
    Related
    ENSMUSP00000096379.4, ENSMUST00000098782.4
    Conserved Domains (1) summary
    cd03595
    Location:38 → 186
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50966323..50988501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510330.5 → XP_006510393.1  layilin isoform X2

    Conserved Domains (1) summary
    cd03595
    Location:38 → 186
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

  2. XM_006510329.4 → XP_006510392.1  layilin isoform X1

    UniProtKB/TrEMBL
    A4QPF5
    Conserved Domains (2) summary
    cd03595
    Location:30 → 178
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin
    pfam15102
    Location:185 → 317
    TMEM154; TMEM154 protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C351.4 GenPept UniProtKB/Swiss-Prot:Q8C351

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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