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Layn layilin [ Mus musculus (house mouse) ]

Gene ID: 244864, updated on 27-Feb-2024

Summary

Official Symbol
Laynprovided by MGI
Official Full Name
layilinprovided by MGI
Primary source
MGI:MGI:2685357
See related
Ensembl:ENSMUSG00000060594 AllianceGenome:MGI:2685357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm511; E030012M19Rik
Summary
Predicted to enable hyaluronic acid binding activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain and trigeminal ganglion. Orthologous to human LAYN (layilin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.6), ovary adult (RPKM 1.5) and 25 other tissues See more
Orthologs
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Genomic context

See Layn in Genome Data Viewer
Location:
9 A5.3; 9 27.79 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50966323..50988501, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (51055023..51077209, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene predicted gene, 25558 Neighboring gene salt inducible kinase 2 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene microRNA 34b Neighboring gene BTG anti-proliferation factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033534.1NP_001028706.1  layilin precursor

    See identical proteins and their annotated locations for NP_001028706.1

    Status: VALIDATED

    Source sequence(s)
    AC119831
    Consensus CDS
    CCDS52791.1
    UniProtKB/Swiss-Prot
    E9QQ23, Q3TMU7, Q8C351
    UniProtKB/TrEMBL
    A4QPF5
    Related
    ENSMUSP00000096379.4, ENSMUST00000098782.4
    Conserved Domains (1) summary
    cd03595
    Location:38186
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50966323..50988501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510330.5XP_006510393.1  layilin isoform X2

    Conserved Domains (1) summary
    cd03595
    Location:38186
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin
  2. XM_006510329.4XP_006510392.1  layilin isoform X1

    UniProtKB/TrEMBL
    A4QPF5
    Conserved Domains (2) summary
    cd03595
    Location:30178
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin
    pfam15102
    Location:185317
    TMEM154; TMEM154 protein family